{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:14Z","timestamp":1789647914705,"version":"4.0.0"},"reference-count":177,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P01\u2010HD104436"],"award-info":[{"award-number":["P01\u2010HD104436"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS110887"],"award-info":[{"award-number":["R01\u2010NS110887"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Mechanisms of Disease"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural tube closure (NTC) is crucial for proper development of the brain and spinal cord and requires precise morphogenesis from a sheet of cells to an intact three\u2010dimensional structure. NTC is dependent on successful regulation of hundreds of genes, a myriad of signaling pathways, concentration gradients, and is influenced by epigenetic and environmental cues. Failure of NTC is termed a neural tube defect (NTD) and is a leading class of congenital defects in the United States and worldwide. Though NTDs are all defined as incomplete closure of the neural tube, the pathogenesis of an NTD determines the type, severity, positioning, and accompanying phenotypes. In this review, we survey pathogenesis of NTDs relating to disruption of cellular processes arising from genetic mutations, altered epigenetic regulation, and environmental influences by micronutrients and maternal condition.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Congenital Diseases &gt; Genetics\/Genomics\/Epigenetics<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Neurological Diseases &gt; Genetics\/Genomics\/Epigenetics<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Neurological Diseases &gt; Stem Cells and Development<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1559","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T23:34:55Z","timestamp":1651620895000},"source":"Crossref","is-referenced-by-count":25,"title":["Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-4320","authenticated-orcid":false,"given":"David M.","family":"Engelhardt","sequence":"first","affiliation":[{"name":"Molecular Cellular Developmental Biology University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-0245","authenticated-orcid":false,"given":"Cara A.","family":"Martyr","sequence":"additional","affiliation":[{"name":"Molecular Cellular Developmental Biology University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-0594","authenticated-orcid":false,"given":"Lee","family":"Niswander","sequence":"additional","affiliation":[{"name":"Molecular Cellular Developmental Biology University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.855001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.179192"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.11055-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700384RR"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123539"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.002766"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00031"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90312-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.512517"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21589"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr031"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.22.4891"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00066-07"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn262"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36456"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.08.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-019-0630-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2020.0362"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22853"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81732-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.5.1229"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.6.686"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934713100"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1783-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500026102"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.10.3575-3582.2003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1181"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80478-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200043"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20211"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.04.020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-89512-3_11"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90071-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.164574"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.7.1281"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.09.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-005-0017-3"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.356394"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414555112"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.4.575"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062066299"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.01.001"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21372-4"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.08.002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9150(00)00739-5"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.03.023"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.6969"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3791\/3132"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515005322"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp347"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.10.012"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0108"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm221"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.11.054"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20333"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20676"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1983"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj166"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.090183"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-164-7:241"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1398"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0450-y"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91895-7"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/13802"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00238"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10094352"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.24.3136"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.146811"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.292"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22844"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23079"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23455"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079478"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/90081"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.04.018"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.04.012"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.005"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.04.009"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.072"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90611-F"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2019-0279"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23397"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.169797"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1624"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0611-7"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-020-01338-4"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02677"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws190"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.11.036"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.048744"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr289"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900333106"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93453-G"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21224"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23223"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211199110"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2493-4"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106.4.787"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2012.12.001"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.08.003"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr585"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0494-357"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.145904"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.021"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.019646"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.043471"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81656-6"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470514559.ch5"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10007"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.11.070"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.002"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21109"},{"issue":"6","key":"e_1_2_9_120_1","first-page":"487","article-title":"Developmentally regulated expression of the transcriptional cofactors\/histone acetyltransferases CBP and p300 during mouse embryogenesis","volume":"43","author":"Partanen A.","year":"1999","journal-title":"The International Journal of Developmental Biology"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-019-0312-7"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/13861"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.045"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.183269"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.02.027"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2020.106319"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab657"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129825"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.23623"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30381-6"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.07.017"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/78124"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13273"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-143"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031145"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23589"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.179"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20680"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.04.023"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.056622"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510310103"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E12-02-0097"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002668"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1591"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1243126"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23542"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.051"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042234"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.21.1.255"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052410099"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.641831"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700092R"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.07.002"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(95)91743-8"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.3.1163"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.10.024"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00123"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1094"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1277298"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23422"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.03.340"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120213-092208"},{"issue":"1","key":"e_1_2_9_163_1","first-page":"1","article-title":"Updated estimates of neural tube defects prevented by mandatory folic acid fortification\u2014United States, 1995\u20102011","volume":"64","author":"Williams J.","year":"2015","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.02.007"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.09.008"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf5089"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16989-w"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201104057"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21885"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106495"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004020"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.10.2507"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.008177"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20704"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151586"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0796-275"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-2035-7"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21011"}],"container-title":["WIREs Mechanisms of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.1559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wsbm.1559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.1559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:26:55Z","timestamp":1692718015000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wsbm.1559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,3]]},"references-count":177,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/wsbm.1559"],"URL":"https:\/\/doi.org\/10.1002\/wsbm.1559","archive":["Portico"],"relation":{},"ISSN":["2692-9368","2692-9368"],"issn-type":[{"value":"2692-9368","type":"print"},{"value":"2692-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,3]]},"article-number":"e1559"}}