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The solution proposed to this problem would consist in the delay of the experiments of perinatal asphyxia (PA), usually up to 7\u201310\u2009days, allowing developmental levels to \u201cequalize\u201d with the human at birth. This solution generates a new set of problems. The developmental milestones in both species follow a divergent temporal pattern. Increasing the age of the rat not only can improve resemblance with humans but also will make the model miss a crucial set of milestones related to birth. During this process, there are specific mechanisms to protect the fetus from neuronal damage, especially those caused by asphyxia. These factors are not present in models where the asphyxia is delayed. 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