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The treatment of active TB cases majorly relies on various anti\u2010tuberculosis drugs. However, under the selection pressure by drugs, the continuous evolution of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) facilitates the emergence of drug\u2010resistant strains, further resulting in the accumulation of tubercle bacilli with multiple drug resistance, especially deadly multidrug\u2010resistant TB and extensively drug\u2010resistant TB. Researches on the mechanism of drug action and drug resistance of Mtb provide a new scheme for clinical management of TB patients, and prevention of drug resistance. In this review, we summarized the molecular mechanisms of drug resistance of existing anti\u2010TB drugs to better understand the evolution of drug resistance of\n                    <jats:italic>Mtb<\/jats:italic>\n                    , which will provide more effective strategies against drug\u2010resistant TB, and accelerate the achievement of the EndTB Strategy by 2035.\n                  <\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Infectious Diseases &gt; Molecular and Cellular Physiology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wsbm.1573","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T18:44:31Z","timestamp":1656269071000},"source":"Crossref","is-referenced-by-count":18,"title":["Resistance and tolerance of\n                    <scp>\n                      <i>Mycobacterium tuberculosis<\/i>\n                    <\/scp>\n                    to antimicrobial agents\u2014How\n                    <scp>\n                      <i>M<\/i>\n                      .\n                      <i>tuberculosis<\/i>\n                    <\/scp>\n                    can escape antibiotics"],"prefix":"10.1002","volume":"14","author":[{"given":"Haoran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Bacteriology and Immunology, Beijing Chest Hospital Capital Medical University\/Beijing Tuberculosis and Thoracic Tumor Research Institute  Beijing 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