{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:54:29Z","timestamp":1790805269963,"version":"4.1.0"},"reference-count":157,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1P01AI102853\u201006"],"award-info":[{"award-number":["1P01AI102853\u201006"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","award":["201610PJT"],"award-info":[{"award-number":["201610PJT"]}],"id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102020\u201005596"],"award-info":[{"award-number":["RGPIN\u20102020\u201005596"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Mechanisms of Disease"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b3\u03b4 T cells are widely distributed throughout mucosal and epithelial cell\u2010rich tissues and are an important early source of IL\u201017 in response to several pathogens. Like \u03b1\u03b2 T cells, \u03b3\u03b4 T cells undergo a stepwise process of development in the thymus that requires recombination of genome\u2010encoded segments to assemble mature T cell receptor (<jats:italic>TCR<\/jats:italic>) genes. This process is tightly controlled on multiple levels to enable <jats:italic>TCR<\/jats:italic> segment assembly while preventing the genomic instability inherent in the double\u2010stranded DNA breaks that occur during this process. Each <jats:italic>TCR<\/jats:italic> locus has unique aspects in its structure and requirements, with different types of regulation before and after the \u03b1\u03b2\/\u03b3\u03b4 T cell fate choice. It has been known that Runx and Myb are critical transcriptional regulators of <jats:italic>TCR\u03b3<\/jats:italic> and <jats:italic>TCR\u03b4<\/jats:italic> expression, but the roles of E proteins in <jats:italic>TCR\u03b3<\/jats:italic> and <jats:italic>TCR\u03b4<\/jats:italic> regulation have been less well explored. Multiple lines of evidence show that E proteins are involved in <jats:italic>TCR<\/jats:italic> expression at many different levels, including the regulation of <jats:italic>Rag<\/jats:italic> recombinase gene expression and protein stability, induction of germline V segment expression, chromatin remodeling, and restriction of the fetal and adult \u03b3\u03b4TCR repertoires. Importantly, E proteins interact directly with the cis\u2010regulatory elements of the <jats:italic>TCR\u03b3<\/jats:italic> and <jats:italic>TCR\u03b4<\/jats:italic> loci, controlling the predisposition of a cell to become an \u03b1\u03b2 T cell or a \u03b3\u03b4 T cell, even before the lineage\u2010dictating TCR signaling events.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Immune System Diseases &gt; Stem Cells and Development<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Immune System Diseases &gt; Genetics\/Genomics\/Epigenetics<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1578","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T08:18:32Z","timestamp":1658132312000},"source":"Crossref","is-referenced-by-count":7,"title":["Direct regulation of TCR rearrangement and expression by E proteins during early T cell development"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-5910","authenticated-orcid":false,"given":"Michele K.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department Immunology Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Dutra Barbosa","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Department Immunology Sunnybrook Research Institute, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1379"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1620"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.11.015"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903218"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12924"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-128-8_7"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/84273"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.8.4782"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1605"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.289"},{"issue":"6","key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.4049\/jimmunol.163.6.3331","article-title":"A novel role for HEB downstream or parallel to the pre\u2010TCR signaling pathway during alpha beta thymopoiesis","volume":"163","author":"Barndt R.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-405943-6.00004-X"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.10.2793"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00455"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211464200"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-676304"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040360"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646407"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01963-w"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.21.12522"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.7.4144"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri797"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.07.005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3031"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.1800072"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127242"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/330722a0"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.004"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242497"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku206"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.030"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-08036-9"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-021-01232-7"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2021.2022661"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.06.005"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190834"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/331627a0"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.733"},{"key":"e_1_2_14_40_1","first-page":"85","volume-title":"Signaling mechanisms regulating T cell diversity and function","author":"Fahl S. P.","year":"2018"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601639"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.023"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90787-7"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125324"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181206"},{"issue":"6","key":"e_1_2_14_46_1","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.4049\/jimmunol.163.6.3076","article-title":"IL\u20104\u2010producing gamma delta T cells that express a very restricted TCR repertoire are preferentially localized in liver and spleen","volume":"163","author":"Gerber D. J.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.769"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1535-6108(02)00236-2"},{"issue":"10","key":"e_1_2_14_49_1","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.4049\/jimmunol.150.10.4244","article-title":"A developmental pathway involving four phenotypically and functionally distinct subsets of CD3\u2010CD4\u2010CD8\u2010triple\u2010negative adult mouse thymocytes defined by CD44 and CD25 expression","volume":"150","author":"Godfrey D. I.","year":"1993","journal-title":"Journal of Immunology"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2413"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20200890"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.04.003"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100468"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/335443a0"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/344068a0"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.014"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2015.1078429"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80071-0"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.11.003"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00426-6"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520908839"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.1.449"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060268"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02225-5"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838144"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.05.011"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.10.014"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-010-8182-x"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250946"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.1997.0069"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7477"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2507"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.11.5.2778-2784.1991"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-48"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903895106"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002766"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.8.2456"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.07.010"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.021"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2010.04.008"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909723106"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.07.011"},{"issue":"5","key":"e_1_2_14_85_1","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.4049\/jimmunol.162.5.2575","article-title":"Characterization of TCR gene rearrangements during adult murine T cell development","volume":"162","author":"Livak F.","year":"1999","journal-title":"Journal of Immunology"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500692"},{"issue":"2","key":"e_1_2_14_87_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4049\/jimmunol.159.2.529","article-title":"Concurrent or sequential delta and beta TCR gene rearrangement during thymocyte development: Individual thymi follow distinct pathways","volume":"159","author":"Margolis D.","year":"1997","journal-title":"Journal of Immunology"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.06.157"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.06.013"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(02)00064-7"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125884"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.659761"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb1455"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.022"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2086"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0305-7"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95837"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.320663.118"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700287"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181402"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402423"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2247"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.101"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr005"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12926"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.11.006"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00948-2"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3224"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102531"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200007)30:7<1988::AID-IMMU1988>3.0.CO;2-W"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182100"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6431-5"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.4.8.10108"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80237-x"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.08.003"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228478"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801650"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2232"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181439"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2702"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.05.034"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302145"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5940"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks556"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00929"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2157"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf0125"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp073"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr055"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06452-11"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.07.002"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209870200"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2809-5_1"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009303"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.013"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302456"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.109"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.24.9203-9211.2000"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.005"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5717"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.03.023"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(02)00285-6"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00478.x"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071275"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1053"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1793709"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.190298"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7546"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115888"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2015.03.007"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12164"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312872111"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800106"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097937"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700146"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.6.3340"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.6.2898"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aao2139"}],"container-title":["WIREs Mechanisms of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.1578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wsbm.1578","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.1578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:26:15Z","timestamp":1692624375000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wsbm.1578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,18]]},"references-count":157,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/wsbm.1578"],"URL":"https:\/\/doi.org\/10.1002\/wsbm.1578","archive":["Portico"],"relation":{},"ISSN":["2692-9368","2692-9368"],"issn-type":[{"value":"2692-9368","type":"print"},{"value":"2692-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,18]]},"article-number":"e1578"}}