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AD is characterized by the aberrant accumulation of \u03b2\u2010amyloid plaques and tau protein\u2010containing neurofibrillary tangles (NFTs) in the brain giving rise to neuroinflammation, oxidative stress, synaptic failure, and eventual neuronal cell death. The total cost of care in AD treatment and related health care activities is enormous and pharmaceutical drugs approved by Food and Drug Administration have not manifested sufficient efficacy in protection and therapy. In recent years, there are growing studies that contribute a fundamental understanding to AD pathogenesis, AD\u2010associated risk factors, and pharmacological intervention. However, greater molecular process\u2010oriented research in company with suitable experimental models is still of the essence to enhance the prospects for AD therapy and cell lines as a disease model are still the major part of this milestone. In this review, we provide an insight into molecular mechanisms, particularly the recent concept in gut\u2010brain axis, vascular dysfunction and autophagy, and current models used in the study of AD. Here, we emphasized the importance of therapeutic strategy targeting multiple mechanisms together with utilizing appropriate models for the discovery of novel effective AD therapy.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Neurological Diseases &gt; Molecular and Cellular Physiology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wsbm.1591","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T21:26:25Z","timestamp":1670621185000},"source":"Crossref","is-referenced-by-count":11,"title":["Beyond the classical amyloid hypothesis in Alzheimer's disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models"],"prefix":"10.1002","volume":"15","author":[{"given":"Atsadang","family":"Theerasri","sequence":"first","affiliation":[{"name":"Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences Chulalongkorn University  Bangkok Thailand"},{"name":"Natural Products for Neuroprotection and Anti\u2010ageing Research Unit Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakawrat","family":"Janpaijit","sequence":"additional","affiliation":[{"name":"Graduate Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences Chulalongkorn University  Bangkok Thailand"},{"name":"Natural Products for Neuroprotection and Anti\u2010ageing Research Unit Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tewin","family":"Tencomnao","sequence":"additional","affiliation":[{"name":"Natural Products for Neuroprotection and Anti\u2010ageing Research Unit Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Clinical Chemistry, Faculty of Allied Health Sciences Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-3077","authenticated-orcid":false,"given":"Anchalee","family":"Prasansuklab","sequence":"additional","affiliation":[{"name":"Natural Products for Neuroprotection and Anti\u2010ageing Research Unit Chulalongkorn University  Bangkok Thailand"},{"name":"College of Public Health Sciences Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102993"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2021.1929210"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2021.102200"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_2_11_6_1","unstructured":"Alzheimer's Disease International. 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