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Invasion of peripheral immune cells into the CNS resulting from an unknown signal or combination of signals results in activation of resident immune cells and the hallmark feature of the disease: demyelinating lesions. These lesion sites are an amalgam of reactive peripheral and central immune cells, astrocytes, damaged and dying oligodendrocytes, and injured neurons and axons. Sustained inflammation affects cells directly located within the lesion site and further abnormalities are apparent diffusely throughout normal\u2010appearing white matter and grey matter. It is only relatively recently, using animal models, new tissue sampling techniques, and next\u2010generation sequencing, that molecular changes occurring in CNS resident cells have been broadly captured. Advances in cell isolation through Fluorescence Activated Cell Sorting (FACS) and laser\u2010capture microdissection together with the emergence of single\u2010cell sequencing have enabled researchers to investigate changes in gene expression in astrocytes, microglia, and oligodendrocytes derived from animal models of MS as well as from primary patient tissue. The contribution of some dysregulated pathways has been followed up in individual studies; however, corroborating results often go unreported between sequencing studies. To this end, we have consolidated results from numerous RNA\u2010sequencing studies to identify and review novel patterns of differentially regulated genes and pathways occurring within CNS glial cells in MS.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Neurological Diseases &gt; Molecular and Cellular Physiology<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1594","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T04:44:49Z","timestamp":1672893889000},"source":"Crossref","is-referenced-by-count":11,"title":["Comparing <scp>RNA<\/scp>\u2010sequencing datasets from astrocytes, oligodendrocytes, and microglia in multiple sclerosis identifies novel dysregulated genes relevant to inflammation and myelination"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7537-3520","authenticated-orcid":false,"given":"Sienna 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