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Infertile PCOS women that need in vitro fertilization (IVF) have greater risk of ovarian hyperstimulation syndrome (OHSS) if conventional ovarian stimulation is used. In vitro oocyte maturation (IVM) is an alternative technique that prevents OHSS in infertile PCOS women. In the last decade, IVM protocols have improved, particularly with the development of biphasic IVM culture accounting for better pregnancy and live birth rates. This technique has been extended to other treatments like, fertility preservation, when patients have no time, or a contra\u2010indication for ovarian stimulation, and poor responders. In this review, we will discuss IVM as a viable option for PCOS infertile patients.<\/jats:p><jats:p>This article is categorized under:<jats:list list-type=\"simple\">\n<jats:list-item><jats:p>Reproductive System Diseases &gt; Molecular and Cellular Physiology<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Reproductive System Diseases &gt; Environmental Factors<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Reproductive System Diseases &gt; Genetics\/Genomics\/Epigenetics<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.1600","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T04:09:37Z","timestamp":1676347777000},"source":"Crossref","is-referenced-by-count":13,"title":["In vitro maturation of oocytes as a laboratory approach to polycystic ovarian syndrome (<scp>PCOS<\/scp>): From oocyte to embryo"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7031-9939","authenticated-orcid":false,"given":"Patricia","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"},{"name":"Escola de Psicologia e Ci\u00eancias da Vida Universidade Lus\u00f3fona de Humanidade e Tecnologia de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-3732","authenticated-orcid":false,"given":"Monica","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Aibar","family":"Manero","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Marujo","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-6632","authenticated-orcid":false,"given":"Carlos E.","family":"Plancha","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico de Assist\u00eancia \u00e0 Reprodu\u00e7\u00e3o \u2013 CEMEARE  Lisbon Portugal"},{"name":"Inst. 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