{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:21:46Z","timestamp":1790277706974,"version":"4.1.0"},"reference-count":235,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Mechanisms of Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The Coronavirus Disease 2019 (COVID\u201019) pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102), has revealed the virus's ability to induce multi\u2010organ damage, including significant liver injury. The molecular mechanisms of liver dysfunction in COVID\u201019 patients are explored, focusing on direct viral infection, immune\u2010mediated damage, and the gut\u2013liver axis. SARS\u2010CoV\u20102 enters liver cells through the Angiotensin\u2010Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) receptors, but alternative pathways, such as CD209\/Dendritic Cell\u2010Specific Intercellular adhesion molecule\u20103\u2010Grabbing Non\u2010integrin (DC\u2010SIGN) and AXL receptors, can also contribute to viral entry. Additionally, immune responses, particularly the cytokine storm, exacerbate liver inflammation, leading to hepatocyte damage. Pre\u2010existing liver conditions, such as metabolic\u2010associated fatty liver disease (MAFLD), alcohol\u2010related liver disease (ALD), and liver fibrosis, heighten the risk of severe outcomes in COVID\u201019 patients. Post\u2010COVID\u201019 liver complications, including fibrosis progression and persistent liver damage, have been reported, with emerging evidence suggesting chronic inflammation, viral persistence, and autoimmune reactions as potential contributors. Furthermore, Drug\u2010Induced Liver Injury (DILI) from COVID\u201019 treatments remains a concern, highlighting the need for careful management. Consequently, understanding the interplay between SARS\u2010CoV\u20102 and the liver is critical for improving patient outcomes and developing targeted therapies to mitigate liver\u2010related complications in both acute and Long COVID\u201019 phases.<\/jats:p>\n                  <jats:p>\n                    This article is categorized under:\n                    <jats:list list-type=\"simple\">\n                      <jats:list-item>\n                        <jats:p>Infectious Diseases &gt; Molecular and Cellular Physiology<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1002\/wsbm.70005","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:13Z","timestamp":1762161073000},"source":"Crossref","is-referenced-by-count":2,"title":["<scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102: A Liver 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