{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:10Z","timestamp":1787757850903,"version":"build-2784847793"},"reference-count":246,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"publisher","award":["D1.2024"],"award-info":[{"award-number":["D1.2024"]}],"id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"publisher","award":["D1.2025"],"award-info":[{"award-number":["D1.2025"]}],"id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Mechanisms of Disease"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Quality control (QC) processes include a network of cellular pathways that prevent the accumulation of toxic aggregates by repairing, recycling, and\/or eliminating defective components, including mitochondria. Among these pathways are the proteostasis network, which regulates the proteome, and mitochondrial quality control (MQC) mechanisms, which maintain mitochondrial number and integrity. QC relies on a hierarchically and spatially integrated regulatory axis rather than individual parallel units. Such systems coordinate mitochondrial biogenesis, dynamics, and autophagic recycling with proteostasis to ensure the maintenance of high\u2010quality mitochondria and bioenergetically efficient cells. Neurons, post\u2010mitotic cells with high energy demands, depend heavily on these mechanisms and on the spatial coordination of MQC. Here, we discuss how failure of this integrated QC axis, rather than dysfunction of its individual components alone, can drive neuronal decline and contribute to the neurodegeneration.<\/jats:p>","DOI":"10.1002\/wsbm.70014","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:38:39Z","timestamp":1787294319000},"source":"Crossref","is-referenced-by-count":0,"title":["Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4190-3875","authenticated-orcid":false,"given":"Rosa","family":"Di Lorenzo","sequence":"first","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Environment Universit\u00e0 Degli Studi di Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0838-0122","authenticated-orcid":false,"given":"Rola S.","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, College of Medicine University of Florida  Gainesville Florida USA"},{"name":"Department of Health Outcomes and Biomedical Informatics, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-2365","authenticated-orcid":false,"given":"Riccardo","family":"Calvani","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Orthopedics and Rheumatology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Environment Universit\u00e0 Degli Studi di Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-6983","authenticated-orcid":false,"given":"Emanuele","family":"Marzetti","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Orthopedics and Rheumatology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"},{"name":"Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-3487","authenticated-orcid":false,"given":"Anna","family":"Picca","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario \u201cAgostino Gemelli\u201d IRCCS  Rome Italy"},{"name":"Department of Medicine and Surgery LUM University  Casamassima Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.614925"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2020.140558"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCISIGNAL.2002712"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.073080"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200803137"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2385\u201016.2017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/NSMB.1592"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2020.102186"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111899"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1534\/GENETICS.106.061580"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.042"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114018"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35014014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.11.024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41556\u2010019\u20100294\u20105"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010026\u201002714\u20104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/NSMB.3147"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/BIES.201000073"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.042"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.03060"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010023\u201000564\u20103"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.201487943"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.10.011"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.01.017"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.09.061"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCOMMS15754"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046293"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200604016"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4161\/cib.29587"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102016\u201004\u2010708750"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07534"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M710012200"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201002100"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3634"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.AAU8857"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2026.02.023"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/JNR.21672"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.07.018"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.21775\/CIMB.035.035"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2019.00517"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200512079"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41593\u2010018\u20100332\u20109"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARR.2024.102549"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.18632\/ONCOTARGET.22287"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.06.002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2472586"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.1342"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.41792"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1160971"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41580\u2010020\u20100210\u20107"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AED3712"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.063"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS4020202"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586\u2010025\u201009987\u20109"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11910"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320531"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.7150\/THNO.59776"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039811\u20109"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.2001.66.499"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097\u20102765(03)00105\u20109"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.062539"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.036"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCB1991"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.016"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV.BIOCHEM.73.011303.073752"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E13\u201002\u20100072"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.10.021"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.048"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41580\u2010019\u20100101\u2010Y"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.114.2.295"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/CDDISCOVERY.2017.76"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13847"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.13943"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u20102\u20109"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200506078"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.002"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.10.007"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAA8714"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABI8886"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/S12276\u2010020\u201000539\u2010X"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010025\u201056673\u20105"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2020.572182"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.142.4.963"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200308075"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/CDD.2015.160"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200611064"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.05.007"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010022\u201034365\u20108"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.0125\u20101"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.027"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.029"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201709072"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TCB.2014.04.004"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.12.003"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2023.10.002"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11010\u2010024\u201005042\u20109"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175088"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FEBSLET.2009.12.047"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201507022"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2022112309"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00018\u2010025\u201006053\u20105"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E02\u201010\u20100657"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.06.004"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200904060"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/S43587\u2010020\u201000025\u2010Z"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0001487"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.201798786"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/EMBOJ\/20.5.941"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1174621"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2015.04.010"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.75658"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1906565116"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E19\u201001\u20100046"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2010.07.005"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E12\u201010\u20100721"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/EMBOJ.2011.384"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.030"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2024.12.007"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1834207"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE05925"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586\u2010019\u20101227\u2010Y"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS262411852"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.039"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200911141"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCB1846"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1505154"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2018.16"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.024"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.012"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010022\u201032564\u2010X"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081847"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/NMETH1055"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.09.055"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010019\u201012382\u20104"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM117.000893"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.014"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0076941"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.02.012"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.367"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12915\u2010018\u20100548\u2010X"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE18302"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.AAT6224"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.EMBOR.7400790"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.02.008"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223560"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCB2708"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.12.038"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/FMOLB.2015.00057"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.65484"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.8.7.1233"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1405755111"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200677200"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2020104705"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV\u2010BIOCHEM\u2010060815\u2010014334"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41556\u2010018\u20100176\u20102"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167547"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809801200"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.10.032"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2007.10.005"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1101\/GAD.992202"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41580\u2010018\u20100092\u20100"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030537"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000930\u20108"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MITO.2015.10.001"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408783769571"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/FEBS.13820"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.10.072"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1009664"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1101\/GAD.316547.118"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41580\u2010019\u20100180\u20109"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.027"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2025.07.011"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201702058"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1136\/GUTJNL\u20102011\u2010300767"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.12.031"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.09.015"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.049"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRM2199"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20112208"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2011.11.003"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3440"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV\u2010BIOPHYS\u2010121219\u2010081604"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21695"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.12.004"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201612111"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.06.006"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.200907074"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.13875"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/NCHEMBIO.1059"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/CR.2016.118"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534\u20105807(02)00203\u20104"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRN3156"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A034033"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010020\u201020784\u2010Y"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.110"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2026.02.026"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600559"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.8.2245"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1605844113"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.057"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2019104105"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E25\u201006\u20100302"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.011"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010995408343"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41586\u2010023\u201006142\u20100"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608073"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201010\u20104567\u20107_3"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007013"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1666594"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNMOL.2022.947191"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.011"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/S42255\u2010026\u201001537\u20105"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601963"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ADH8228"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011072"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.03.009"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.014"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1093\/HMG\/DDAE031"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1209038"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20112050"},{"key":"e_1_2_11_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.009"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316823120"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE14859"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE25003"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAN4146"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.03.001"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE14951"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.201510098"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41531\u2010022\u201000402\u2010Y"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1007\u20101102"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1083\/JCB.202201071"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E10\u201009\u20100748"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAN0178"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1002\/MCO2.70319"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.EMBOJ.7601249"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41556\u2010021\u201000724\u20108"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.029"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf445"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.026"},{"key":"e_1_2_11_244_1","doi-asserted-by":"publisher","DOI":"10.1002\/ADVS.202408503"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABB2529"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.09.008"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41467\u2010018\u201004564\u20103"}],"container-title":["WIREs Mechanisms of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.70014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wsbm.70014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:50Z","timestamp":1787756090000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wsbm.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":246,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/wsbm.70014"],"URL":"https:\/\/doi.org\/10.1002\/wsbm.70014","archive":["Portico"],"relation":{},"ISSN":["2692-9368","2692-9368"],"issn-type":[{"value":"2692-9368","type":"print"},{"value":"2692-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"e70014"}}