{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:33:11Z","timestamp":1793086391742,"version":"4.5.0"},"reference-count":86,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WIREs Mechanisms of Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fatty acid synthase (FASN) is the key catalytic enzyme of de novo lipogenesis and is increasingly recognized as a driver of metabolic reprogramming in genitourinary disease. In both malignant and non\u2010malignant settings, aberrant FASN expression and activity are associated with tumor growth, metastatic spread, drug resistance, renal lipotoxicity, fibrosis, and immune remodeling. However, current evidence remains scattered across organ\u2010specific studies, and a focused synthesis across the genitourinary system is still lacking. This review summarizes the expression patterns, upstream regulators, downstream effects, and translational relevance of FASN in major genitourinary organs, with emphasis on the bladder, kidney, prostate, cervix, and ovary, as well as selected benign disorders. We also review current therapeutic strategies, including direct FASN inhibition, modulation of upstream lipogenic pathways, nanodelivery approaches, and rational combination regimens with chemotherapy, endocrine therapy, or immunotherapy. Available data support FASN as a shared metabolic node linking lipid reprogramming to both malignant progression and organ injury. In bladder, renal, prostate, and cervical cancers, FASN contributes to proliferation, invasion, metastasis, and treatment resistance. In renal and reproductive disorders, it is also involved in lipid deposition, inflammation, fibrosis, and ovulatory dysfunction. Despite promising preclinical findings, major challenges remain, including limited evidence in benign disease, marked mechanistic heterogeneity across organs, and insufficient clinical validation of biomarkers and targeted agents. A more integrated understanding of FASN may improve biomarker development and support metabolism\u2010based precision therapy in genitourinary disease.<\/jats:p>","DOI":"10.1002\/wsbm.70018","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:32:24Z","timestamp":1792643544000},"source":"Crossref","is-referenced-by-count":0,"title":["<scp>FASN<\/scp>\n                    as a Therapeutic Target in Genitourinary Diseases: From Cancers to Benign Disorders"],"prefix":"10.1002","volume":"18","author":[{"given":"Canfeng","family":"Zhou","sequence":"first","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"},{"name":"Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanze","family":"Guo","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"},{"name":"Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Facai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-4586","authenticated-orcid":false,"given":"William C.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Queen Elizabeth Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-7902","authenticated-orcid":false,"given":"Koo Han","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Urology Kyung Hee University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-013X","authenticated-orcid":false,"given":"Pu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-7878","authenticated-orcid":false,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8587-6959","authenticated-orcid":false,"given":"Dechao","family":"Feng","sequence":"additional","affiliation":[{"name":"Urology &amp; Nephrology Center, Department of Urology Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College  Hangzhou Zhejiang China"},{"name":"Division of Surgery &amp; Interventional Science University College London  London UK"},{"name":"Clinical Medicine Research Institute Zhejiang Provincial People's Hospital of Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13476"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.70025"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-17-0410"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11040618"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.70064"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29890"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04400-3"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314717"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1604758"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03874-5"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1746812"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1243-2"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00493-8"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24258"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1122570"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01185"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04926-2"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100797"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010073"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.757592"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5612"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22732"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511002613"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.02.003"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00447"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.186"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153806"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203730"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13684"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2807"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031209"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3645"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-009-1230-4"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4673"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.1133"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-025-02867-8"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504688"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2017.06.006"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2024.28.3.219"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124359"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2024192"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07782-y"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403390101"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.70002"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.03.025"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0585"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0306575"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34029"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1630"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.45640"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.1221"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1430583"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06090-7"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01553-z"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.04.013"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883241273305"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12956"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1634"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104778"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-010-0517-0"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110650200"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-025-01645-y"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27129"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.04.007"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-023-01288-8"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-07298-x"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.06.006"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.1156"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83051"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118292"},{"issue":"2","key":"e_1_2_15_72_1","first-page":"568","article-title":"Association Between Different Levels of Lipid Metabolism\u2011Related Enzymes and Fatty Acid Synthase in Wilms' Tumor","volume":"56","author":"Wang X.","year":"2020","journal-title":"International Journal of Oncology"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-025-02431-x"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-024-10703-x"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2328"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13793"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1654-6"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.836939"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153227"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808834116"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-67083-y"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.915592"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156776"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02581-5"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.87203"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04867-8"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02424-5"}],"container-title":["WIREs Mechanisms of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.70018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/wsbm.70018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/wsbm.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:38:59Z","timestamp":1793083139000},"score":1,"resource":{"primary":{"URL":"https:\/\/wires.onlinelibrary.wiley.com\/doi\/10.1002\/wsbm.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":86,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/wsbm.70018"],"URL":"https:\/\/doi.org\/10.1002\/wsbm.70018","archive":["Portico"],"relation":{},"ISSN":["2692-9368","2692-9368"],"issn-type":[{"value":"2692-9368","type":"print"},{"value":"2692-9368","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"e70018"}}