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Early in life, workers perform brood care and other in\u2010hive tasks and have large internal nutrient stores; later in life, they forage for nectar and pollen outside the hive and have small nutrient stores. The pace of maturation depends on colony conditions, and the environmental, physiological, and genomic mechanisms by which this occurs are being actively investigated. Here we review current knowledge of the mechanisms by which a key environmental variable, nutritional status, influences worker honey bee division of labor. These studies demonstrate that changes in individual nutritional status and conserved food\u2010related molecular and hormonal pathways regulate the age at which individual bees begin to forage. We then outline ways in which systems biology approaches, enabled by the sequencing of the honey bee genome, will allow researchers to gain deeper insight into nutritional regulation of honey bee behavior, and phenotypic plasticity in general. Copyright \u00a9 2010 John Wiley &amp; Sons, Inc.<\/jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Physiology &gt; Physiology of Model Organisms<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/wsbm.73","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T02:08:41Z","timestamp":1265335721000},"page":"566-576","source":"Crossref","is-referenced-by-count":119,"title":["Nutritional regulation of division of labor in honey bees: toward a systems biology perspective"],"prefix":"10.1002","volume":"2","author":[{"given":"Seth A.","family":"Ament","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene 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