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Among these, the\n                    <jats:italic>SOD2<\/jats:italic>\n                    gene encoding mitochondrial MnSOD was disrupted and overexpressed to investigate its roles in\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . The null mutant lacking mitochondrial MnSOD was more sensitive than wild\u2010type cells to various stresses, such as redox\u2010cycling agents, heating, ethanol, high concentration of sodium or potassium and 99.9% O\n                    <jats:sub>2<\/jats:sub>\n                    . Interestingly, the\n                    <jats:italic>sod2\/sod2<\/jats:italic>\n                    mutant was rather more resistant to lithium and diamide than the wild\u2010type, whereas overexpression of\n                    <jats:italic>SOD2<\/jats:italic>\n                    increased susceptibility of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    to these compounds. The inverse effect of mitochondrial MnSOD on lithium toxicity was relieved when the\n                    <jats:italic>sod2\/sod2<\/jats:italic>\n                    and\n                    <jats:italic>SOD2<\/jats:italic>\n                    \u2010overexpressing cells were grown on the synthetic dextrose medium containing sulphur compounds such as methionine, cysteine, glutathione or sulphite, indicating that mitochondrial MnSOD may affect lithium toxicity through sulphur metabolism. Moreover, disruption or overexpression of\n                    <jats:italic>SOD2<\/jats:italic>\n                    increased or decreased glutathione reductase activity and cyanide\u2010resistant respiration by alternative oxidase, respectively. Taken together, these findings suggest that mitochondrial MnSOD is important for stress responses, lithium toxicity and cyanide\u2010resistant respiration of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/yea.1004","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T06:14:40Z","timestamp":1059459280000},"page":"929-941","source":"Crossref","is-referenced-by-count":78,"title":["Protective roles of mitochondrial manganese\u2010containing superoxide dismutase against various stresses in\n                    <i>Candida 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