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We have cloned, identified and expressed for functional complementation a PMR1\u2010like Ca<jats:sup>2+<\/jats:sup>\u2010ATPase gene from <jats:italic>A. fumigatus<\/jats:italic>. The <jats:italic>Afpmr1<\/jats:italic> gene encodes a protein of 1061 deduced amino acids, containing all the conserved subdomains found in other P\u2010type ATPases: the phosphatase region, phosphorylation site, FITC labelling site, ATP binding domain; E<jats:sub>386<\/jats:sub>, N<jats:sub>871<\/jats:sub>, D<jats:sub>875<\/jats:sub> amino acid residues for calcium ion interaction and Q<jats:sub>880<\/jats:sub>, a residue that alters ion selectivity in PMR1. The expressed <jats:italic>Af<\/jats:italic>PMR1 in <jats:italic>S. cerevisiae<\/jats:italic> K616 strain functionally complemented the deficient growth in EGTA (5\u201320 m<jats:sc>M<\/jats:sc>)\u2010 and MnCl<jats:sub>2<\/jats:sub> (4 m<jats:sc>M<\/jats:sc>)\u2010containing medium. These results demonstrate the first evidence of a Ca<jats:sup>2+<\/jats:sup>\u2010ATPase in <jats:italic>A. fumigatus<\/jats:italic> and strongly suggest a role for this enzyme in calcium and manganese homeostasis. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/yea.1280","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T14:17:51Z","timestamp":1123510671000},"page":"813-824","source":"Crossref","is-referenced-by-count":18,"title":["A PMR1\u2010like calcium ATPase of <i>Aspergillus fumigatus<\/i>: cloning, identification and functional expression in <i>S. cerevisiae<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"F. M.","family":"Soriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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