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We demonstrate here that deficiency of Cwt1 leads to decreased \u03b21,6\u2010glucan in the cell wall, while mannoproteins are increased in the cell wall of exponentially growing cells and are released into the medium of stationary phase cells. Hyphal morphogenesis of <jats:italic>cwt1<\/jats:italic> mutants is reduced on the surfaces of some inducing media. Unexpectedly, the <jats:italic>CWT1<\/jats:italic>\/<jats:italic>cwt1<\/jats:italic> heterozygous strains shows some stronger <jats:italic>in vitro<\/jats:italic> phenotypes compared to the homozygous mutant. The heterozygous but not the homozygous strain is also strongly impaired for its virulence in a mouse model of systemic infection. We suggest that an intermediate dosage of Cwt1 affects phenotypes profoundly, while its complete absence may elicit compensatory responses of <jats:italic>C. albicans<\/jats:italic>. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/yea.1733","type":"journal-article","created":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T03:30:36Z","timestamp":1257910236000},"page":"77-87","source":"Crossref","is-referenced-by-count":12,"title":["Dosage\u2010dependent roles of the Cwt1 transcription factor for cell wall architecture, morphogenesis, drug sensitivity and virulence in C<i>andida albicans<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Inmaculada","family":"Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Martinez\u2010Esparza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie 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