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Surprisingly, in addition to the cytoplasmic localization, CaPtc2p is partially associated with mitochondria in yeast\u2010form and filamentous cells of <jats:italic>C. albicans<\/jats:italic>. Expression of <jats:italic>CaPTC2<\/jats:italic> is developmentally regulated during the serum\u2010induced filamentation. Deletion of <jats:italic>CaPTC2<\/jats:italic> renders <jats:italic>C. albicans<\/jats:italic> cells sensitive to SDS and azole antifungals, as well as the DNA methylation agent methylmethane sulphonate and the DNA synthesis inhibitor hydroxyurea. Therefore, CaPtc2p might fulfil multiple functions, including the regulation of mitochondrial physiology and checkpoint recovery from DNA damage in <jats:italic>C. albicans<\/jats:italic> cells. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/yea.1778","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T12:50:21Z","timestamp":1272286221000},"page":"753-764","source":"Crossref","is-referenced-by-count":22,"title":["Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen <i>Candida 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