{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:48:56Z","timestamp":1762375736046},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Yeast"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This longitudinal prospective study aimed to determine the prevalence of oropharyngeal colonization by <jats:italic>C. albicans<\/jats:italic> in children with cystic fibrosis (CF), and observe the continuity of candidal colonization and the changes in production of virulence factors, susceptibility to antifungal agents and RAPD patterns of the isolates. Thirty\u2010seven children with CF were followed\u2010up for oropharyngeal <jats:italic>C. albicans<\/jats:italic> colonization for 18\u2009months. The colonization rate was detected in 54%. All isolates were susceptible to amphotericin B, but those isolated from one patient were resistant to fluconazole. Biofilm production, secretory acid proteinase, phospholipase and esterase activity rates were 30%, 60%, 75% and 80%, respectively. RAPD analysis with the primers OPE\u201003 and OPE\u201018 was performed for genotyping. RAPD patterns of the strains isolated from the same patient were related to each other, whereas they were not related with other strains isolated from different patients. Two <jats:italic>C. albicans<\/jats:italic> strains isolated from the same patient were found to be unrelated to one another. As a result, long\u2010lasting colonization of the oropharyngeal mucosa of children with CF by endogenous <jats:italic>C. albicans<\/jats:italic> isolates having the same RAPD pattern was demonstrated. Colonization prevalance and development of resistance to antifungal agents and the increased production of virulence factors were not correlated. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/yea.2977","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T12:57:49Z","timestamp":1376312269000},"page":"429-436","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term oropharyngeal colonization by <i>C. albicans<\/i> in children with cystic fibrosis"],"prefix":"10.1002","volume":"30","author":[{"given":"Meral","family":"Karaman","sequence":"first","affiliation":[{"name":"Multidisciplinary Laboratories Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Firinci","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozkan","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Hakki Bahar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Dokuz Eylul University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.922.455"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365540903348336"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.6.1332-1336.1997"},{"key":"e_1_2_6_5_1","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts. 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