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Exposure to BA causes a rapid and reversible disappearance of polarisome and Spitzenk\u00f6rper in growing hyphae. In BA\u2010treated hyphae of <jats:italic>C. albicans<\/jats:italic>, actin quickly reorganizes from cytoplasmic cables to cortical patches and cell wall growth switches from an apical to an isotropic pattern. As a result of the cytoskeletal changes, the hyphal tips broaden and directional growth of hyphae ceases in the presence of BA. An analysis of homozygous deletion strains showed that mutants with constitutive or enhanced hyphal growth (<jats:italic>tup1<\/jats:italic>, <jats:italic>nrg1<\/jats:italic>, <jats:italic>ssn6<\/jats:italic>, <jats:italic>rbf1<\/jats:italic>) are BA\u2010sensitive, demonstrating that cellular morphology is a major determinant of BA tolerance. The screening of deletion mutants also showed that deficiencies of the main activator of hyphal gene expression, Efg1, and the Rim101\u2010signalling cascade, leading to Efg1 activation, cause BA resistance. Taken together, the data presented show that the selective inhibitory effect on BA on <jats:italic>C. albicans<\/jats:italic> hyphae is rooted in a disruption of apical cytoskeletal elements of growing hyphae. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/yea.3066","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T08:52:13Z","timestamp":1433753533000},"page":"389-398","source":"Crossref","is-referenced-by-count":31,"title":["Boric acid destabilizes the hyphal cytoskeleton and inhibits invasive growth of <i>Candida albicans<\/i>"],"prefix":"10.1002","volume":"32","author":[{"given":"Benjamin R.","family":"Pointer","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Nutrition Des Moines University  IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Nutrition Des Moines University  IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Nutrition Des Moines 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