{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:24:41Z","timestamp":1767626681082},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,1,29]],"date-time":"2004-01-29T00:00:00Z","timestamp":1075334400000},"content-version":"vor","delay-in-days":4198,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Yeast"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Saccharomyces<\/jats:italic> strains capable of fermenting maltose contain any one of five telomere\u2010associated <jats:italic>MAL<\/jats:italic> loci. Each <jats:italic>MAL<\/jats:italic> locus is a complex of three genes encoding the three functions required to ferment maltos: maltose permease (GENE 1), maltase (GENE 2) and the <jats:italic>MAL trans<\/jats:italic>\u2010activator (GENE 3). All five loci have been cloned and all are highly sequence homologous over least a 9\u20100 kbp region containing these GENEs (Charron <jats:italic>et al.<\/jats:italic>, <jats:italic>Genetics<\/jats:italic> <jats:bold>122<\/jats:bold>, 307\u2013331, 1989). Our initial studies of strians carrying the <jats:italic>MAL3<\/jats:italic> locus indicated the presence of linked, repeated <jats:italic>MLA<\/jats:italic>\u2010homologous sequences (Michels and Needleman, <jats:italic>Mol. Gen. Genet.<\/jats:italic> <jats:bold>191<\/jats:bold>, 225\u2013230, 1983). Here we report our analysis of the centromere\u2010proximal <jats:italic>MAL3<\/jats:italic>\u2010linked sequence and show that the complete <jats:italic>MAL3<\/jats:italic> locus spans approximately 40 kbp and consists of tandemly arrayed, partial repeats of the three GENE sequences described above. In addition, the structure of the <jats:italic>MAL3<\/jats:italic> locus is compared to that of three partially functional alleles of <jats:italic>MAL3<\/jats:italic>. These alleles were shown to contain only <jats:italic>MAL31<\/jats:italic> and <jats:italic>MAL32<\/jats:italic> and their structure suggests that they resulted from <jats:italic>MAL3<\/jats:italic> deletions removing the sequences centromere\u2010proximal of <jats:italic>MAL31<\/jats:italic>. The amplification and rerrangement of the telomer\u2010linked <jats:italic>MAL3<\/jats:italic> sequences are discussed in the context of studies on other telemere\u2010associated sequences from yeast and other species.<\/jats:p>","DOI":"10.1002\/yea.320080809","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T23:39:51Z","timestamp":1117323591000},"page":"655-665","source":"Crossref","is-referenced-by-count":33,"title":["The telomere\u2010associated <i>MAL3<\/i> locus of <i>Saccharomyces<\/i> is a tandem array of repeateed genes"],"prefix":"10.1002","volume":"8","author":[{"given":"Corinne A.","family":"Michels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyl","family":"Nat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen J.","family":"Charron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2442","article-title":"Effect of limited homology on gene conversion in a Saccharomyces cerevisiae plasmid recombination system","volume":"8","author":"Ahn B.\u2010Y.","year":"1988","journal-title":"Mol. 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