{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:21:11Z","timestamp":1780960871220,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Yeast"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A set of 185 strains of <jats:styled-content style=\"fixed-case\"><jats:italic>Candida albicans<\/jats:italic><\/jats:styled-content> from patients with vulvovaginal candidiasis (VVC) and from non\u2010VVC clinical sources in southwest China was analysed. Strains were subjected to genotyping using CAI microsatellite typing and amplification of an intron\u2010containing region of the 25S rRNA gene. Microsatellite genotypes of strains from non\u2010VVC sources showed high polymorphism, whereas those of VVC were dominated by few, closely similar genotypes. However, among non\u2010VVC strains, two genotypes were particularly prevalent in patients with lung cancer. 25S rDNA genotype A was dominant in VVC sources (86.7%), whereas genotypes A, B, and C were rather evenly distributed among non\u2010VVC sources; known genotypes D and E were not found. In an experimental mouse model, isolates from lung cancer and AIDS patients proved to have higher virulence than VVC strains. Among 156 mice infected with <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0albicans<\/jats:italic><\/jats:styled-content>, 19 developed non\u2010invasive urothelial carcinoma. No correlation could be established between parameters of virulence, source of infection, and incidence of carcinoma. <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0albicans<\/jats:italic><\/jats:styled-content> strains from VVC were less susceptible to itraconazole than the strains from non\u2010VVC sources, whereas there was small difference in antifungal susceptibility between different 25S rDNA genotypes of <jats:styled-content style=\"fixed-case\"><jats:italic>C.\u00a0albicans<\/jats:italic><\/jats:styled-content> tested against amphotericin B, itraconazole, fluconazole, and flucytosine.<\/jats:p>","DOI":"10.1002\/yea.3397","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T02:10:29Z","timestamp":1556676629000},"page":"363-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Virulence and antifungal susceptibility of microsatellite genotypes of <scp><i>Candida albicans<\/i><\/scp> from superficial and deep locations"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-1256","authenticated-orcid":false,"given":"Meizhu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou &amp; Guizhou Talent Base for Microbiology and Human Health, Key Laboratory of Medical Microbiology and Parasitology of Education Department of Guizhou, School of Basic Medical Sciences Guizhou Medical University  Guiyang China"},{"name":"Westerdijk Fungal Biodiversity Institute  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Big Health Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoning","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory People's Hospital of Dazu District  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-2647","authenticated-orcid":false,"given":"Abdullah M.S.","family":"Al\u2010Hatmi","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute  Utrecht The Netherlands"},{"name":"Ministry of Health Directorate General of Health Services  Ibri Oman"},{"name":"Centre of Expertise in Mycology of Radboudumc\/Canisius Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizheng","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Clinical Lab Guiyang Public Health Treatment Center  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Infection Control Section The Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy A.","family":"Sibirny","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Microbiology University of Rzeszow  Rzeszow Poland"},{"name":"Institute of Cell Biology NAS of Ukraine  Lviv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou &amp; 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