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The process of adhesion and further biofilm development depends, in part, on cell surface hydrophobicity (CSH). In this study, we compared the resistance of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains with different CSH to the most commonly prescribed antifungal drug, fluconazole, and the newly described synergistic combination, fluconazole and gentamicin. The hydrophobic strain was more resistant to fluconazole due to, among others, overexpression of the\n                    <jats:italic>ERG11<\/jats:italic>\n                    gene encoding the fluconazole target protein (CYP51A1, Erg11p), which leads to overproduction of ergosterol in this strain. Additionally, the hydrophobic strain displayed high efflux activity of the multidrug resistance Cdr1 pump due to high expression of the\n                    <jats:italic>CDR1<\/jats:italic>\n                    gene. On the other hand, the hydrophobic\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain was more susceptible to fluconazole\u2013gentamicin combination because of its different effect on lipid content in the two strains. The combination resulted in ergosterol depletion with subsequent Cdr1p mislocalization and loss of activity in the hydrophobic strain. We propose that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains with different CSH may possess altered lipid metabolism and consequently may differ in their response to treatment.\n                  <\/jats:p>","DOI":"10.1002\/yea.3455","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T14:08:25Z","timestamp":1576073305000},"page":"117-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Lipid composition and cell surface hydrophobicity of\n                    <scp>\n                      <i>Candida albicans<\/i>\n                    <\/scp>\n                    influence the efficacy of fluconazole\u2013gentamicin treatment"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-638X","authenticated-orcid":false,"given":"Jakub","family":"Suchodolski","sequence":"first","affiliation":[{"name":"Department of Biotransformation, Faculty of Biotechnology University of Wroc\u0142aw  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Muraszko","sequence":"additional","affiliation":[{"name":"Department of Biotransformation, Faculty of Biotechnology University of Wroc\u0142aw  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Korba","sequence":"additional","affiliation":[{"name":"Department of Biotransformation, Faculty of Biotechnology University of Wroc\u0142aw  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Bernat","sequence":"additional","affiliation":[{"name":"Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krasowska","sequence":"additional","affiliation":[{"name":"Department of Biotransformation, Faculty of Biotechnology University of Wroc\u0142aw  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.29252\/cmm.3.1.13"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0059"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-2375-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199677"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-015-0486-3"},{"key":"e_1_2_7_7_1","volume-title":"Reference method for broth dilutionantifungal susceptibility testing of yeast. 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