{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:02Z","timestamp":1791234722751,"version":"4.1.0"},"reference-count":231,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["694633"],"award-info":[{"award-number":["694633"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["722287"],"award-info":[{"award-number":["722287"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["694633"],"award-info":[{"award-number":["694633"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Yeast"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemically defined media for yeast cultivation (CDMY) were developed to support fast growth, experimental reproducibility, and quantitative analysis of growth rates and biomass yields. In addition to mineral salts and a carbon substrate, popular CDMYs contain seven to nine B\u2010group vitamins, which are either enzyme cofactors or precursors for their synthesis. Despite the widespread use of CDMY in fundamental and applied yeast research, the relation of their design and composition to the actual vitamin requirements of yeasts has not been subjected to critical review since their first development in the 1940s. Vitamins are formally defined as essential organic molecules that cannot be synthesized by an organism. In yeast physiology, use of the term \u201cvitamin\u201d is primarily based on essentiality for humans, but the genome of the <jats:italic>Saccharomyces cerevisiae<\/jats:italic> reference strain S288C harbours most of the structural genes required for synthesis of the vitamins included in popular CDMY. Here, we review the biochemistry and genetics of the biosynthesis of these compounds by <jats:italic>S. cerevisiae<\/jats:italic> and, based on a comparative genomics analysis, assess the diversity within the <jats:italic>Saccharomyces<\/jats:italic> genus with respect to vitamin prototrophy.<\/jats:p>","DOI":"10.1002\/yea.3461","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T18:00:45Z","timestamp":1579802445000},"page":"283-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Vitamin requirements and biosynthesis in <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-3292","authenticated-orcid":false,"given":"Thomas","family":"Perli","sequence":"first","affiliation":[{"name":"Department of Biotechnology Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-3039","authenticated-orcid":false,"given":"Anna K.","family":"Wronska","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-8941","authenticated-orcid":false,"given":"Ra\u00fal A.","family":"Ortiz\u2010Merino","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-4611","authenticated-orcid":false,"given":"Jack T.","family":"Pronk","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-8193","authenticated-orcid":false,"given":"Jean\u2010Marc","family":"Daran","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-002-1092-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.60.1.44-69.1996"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.111.000422"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05729.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030410103"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030430303"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01252.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-016-0485-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msv168"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evy132"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1979.tb06277.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310311200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90078-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.19.7044-7054.2003"},{"key":"e_1_2_8_16_1","first-page":"110","article-title":"Beziehungen zwischen selektiver Ultraviolett\u2010Absorption mit chemischer Konstitution","volume":"28","author":"Behaghel O.","year":"1928","journal-title":"Strahlentherapie"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.024"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088493"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00416-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/genetics\/131.3.531","article-title":"Serine and threonine catabolism in Saccharomyces cerevisiae: The CHA1 polypeptide is homologous with other serine and threonine dehydratases","volume":"131","author":"Bornaes C.","year":"1992","journal-title":"Genetics"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.553503"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00892-17"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.55.3.349-370.1991"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/S0021-9258(18)64035-9","article-title":"The biosynthesis of folic acid: I. Substrate and cofactor requirements for enzymatic synthesis by cell\u2010free extracts of Escherichia coli","volume":"236","author":"Brown G. M.","year":"1961","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_26_1","first-page":"965","article-title":"An enzymic analysis of NADPH production and consumption in Candida utilis","volume":"129","author":"Bruinenberg P. M.","year":"1983","journal-title":"Journal of General Microbiology"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1537-2197.1943.tb14749.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.48.4.385-391.1944"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04864.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10503"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja067606t"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja802140a"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787185788"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007103200"},{"key":"e_1_2_8_35_1","volume-title":"The vitamins: Fundamental aspects in nutrition and health","author":"Combs G. F.","year":"2008"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.397240"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1995.tb07724.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.126.1.243-250.1976"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.20.13203"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-4-2-150"},{"key":"e_1_2_8_41_1","first-page":"659","volume-title":"Manual of Industrial Microbiology and Biotechnology","author":"Dahod S. K.","year":"2010"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.480335"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6746"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0723-2020(00)80044-2"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1987.tb11440.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2010.12.006"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.43.26871"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1016\/S0021-9258(19)69102-7","article-title":"myo\u2010Inositol\u20101\u2010phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast","volume":"256","author":"Donahue T. F.","year":"1981","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2003.03973.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184838"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.06.006"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/j150289a015"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002195"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.34.20242"},{"key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0021-9258(18)74164-1","article-title":"The isolation and identification of the anti\u2010black tongue factor","volume":"123","author":"Elvehjem C. A.","year":"1938","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0400426"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.31.19165"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.11.4011"},{"key":"e_1_2_8_59_1","volume-title":"The vitamines","author":"Funk C.","year":"1922"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1139\/W08-150"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/10425179109008435"},{"issue":"546","key":"e_1_2_8_62_1","first-page":"563","article-title":"Life with 6000 genes","volume":"274","author":"Goffeau A.","year":"1996","journal-title":"Science"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/an906310385b"},{"key":"e_1_2_8_64_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/100.1.19","article-title":"Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol\u2010excreting mutants","volume":"100","author":"Greenberg M. L.","year":"1982","journal-title":"Genetics"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)94004-V"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.91.2358.243"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2005.04.001"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.074963"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.057489"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja076604l"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2012.00830.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004380051199"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01874a069"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02625-07"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.12.013"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.130286"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.141.1.270-274.1980"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.173.24.7963-7969.1991"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00279908"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb15442.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(98)00069-7"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401071200"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2540520.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03009-10"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13943"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070642"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006987"},{"key":"e_1_2_8_88_1","first-page":"1390","article-title":"On the isolation of the anti\u2010beri\u2010beri vitamin","volume":"29","author":"Jansen B. C. P.","year":"1926","journal-title":"Proceedings of the Koninklijke Akademie Van Wetenschappen Te Amsterdam"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fox044"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.10.003"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1007"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi001020g"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267608"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.09.008"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2014.07.009"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2001.tb10712.x"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-004-0557-x"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01272a507"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407137200"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01959-1"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-53"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-25"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540500167203"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1935.235.5-6.201"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja302474a"},{"key":"e_1_2_8_106_1","first-page":"721","article-title":"Metabolic functions of biotin; the role of biotin in bicarbonate utilization by Lactobacillus arabinosus studied with 14C","volume":"179","author":"Lardy H. A.","year":"1949","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_107_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/genetics\/129.3.685","article-title":"SUM1\u20101: a suppressor of silencing defects in Saccharomyces cerevisiae","volume":"129","author":"Laurenson P.","year":"1991","journal-title":"Genetics"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.87.2251.169"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01590-09"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00006-1"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-69"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00289.x"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01698-7"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.177.7.1817-1823.1995"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.09.030"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.217885"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/147.2.435"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2008.02.002"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.energy.21.1.403"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1302"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.1999.00319.x"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13648"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2017.10.011"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.151894"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.6.2009-2016.2003"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314439"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.043"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.3.1014-1027.2006"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.4.1252"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb06077.x"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-006-0130-z"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(92)90124-I"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)91334-9"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00449-4"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007656"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01886.x"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(73)90415-4"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.002013"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.13.4347-4368.2001"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.06964.x"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-11-36"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80349-L"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.174.14.4701-4706.1992"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.173.8.2716-2719.1991"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0464-9"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1989.tb03419.x"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04835.x"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12426"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.31.563"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-009-0234-1"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.21.5718-5726.1998"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120951"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02585-1"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04600.x"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406811102"},{"key":"e_1_2_8_156_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1534\/g3.118.200831","article-title":"SNZ3 encodes a PLP synthase involved in thiamine synthesis in Saccharomyces cerevisiae","volume":"9","author":"Paxhia M. D.","year":"2019","journal-title":"Genes|Genomes|Genetics (Bethesda)"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00335-9"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00117-1"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.03.014"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43808"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511075200"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.05.015"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.09.002"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7012(97)00032-8"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320100407"},{"key":"e_1_2_8_166_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0021-9258(18)64875-6","article-title":"Enzymatic synthesis of nicotinamide mononucleotide","volume":"225","author":"Preiss J.","year":"1957","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_167_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0021-9258(18)64789-1","article-title":"Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates","volume":"233","author":"Preiss J.","year":"1958","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.5.2095-2100.2002"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501356200"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.6.2695"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.916"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.47.2.159-170.1944"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01675-12"},{"key":"e_1_2_8_174_1","first-page":"7539","article-title":"Urea amidolyase. The involvement of biotin in urea cleavage","volume":"247","author":"Roon R. J.","year":"1972","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1026"},{"key":"e_1_2_8_176_1","first-page":"729","article-title":"Die Beeinflussung der Lichentz\u00fcndung und der Pigmentierung durch Novokain\u2010Einspritzungen","volume":"22","author":"Rothman S.","year":"1926","journal-title":"Strahlentherapie"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1942.59"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161547"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26087"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fox074"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.111.000273"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb18268.x"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-016-0673-0"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327674"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01876a513"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-09-0642"},{"key":"e_1_2_8_187_1","volume-title":"Methods in yeast genetics: A laboratory course manual","author":"Sherman F.","year":"1987"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.419947.x"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-004-0159-0"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2005.00007.x"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-573"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18741"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300949200"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04663.x"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.6013\/jbrewsocjapan1915.60.453"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114738"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2310157"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.108"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050263"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683089"},{"key":"e_1_2_8_201_1","doi-asserted-by":"crossref","first-page":"12156","DOI":"10.1016\/S0021-9258(18)43247-4","article-title":"Ornithine decarboxylase from Saccharomyces cerevisiae. Purification, properties, and regulation of activity","volume":"256","author":"Tyagi A. K.","year":"1981","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.320080703"},{"key":"e_1_2_8_203_1","volume-title":"Fundamentals of biochemistry life at the molecular level","author":"Voet D.","year":"2006"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1984.tb08321.x"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.6.3276-3284.2005"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.8.4534-4541.2003"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00484-1"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(58)90177-X"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)90414-3"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512158200"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-11-1-104"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)60004-1"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009804200"},{"key":"e_1_2_8_214_1","first-page":"6","article-title":"A critical evaluation of the nitrogen assimilation tests as commonly used in the classification of the yeasts","volume":"51","author":"Wickerham L. J.","year":"1946","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_8_215_1","volume-title":"Taxonomy of yeasts","author":"Wickerham L. J.","year":"1951"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1111\/1567-1364.12115"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26194-0"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01334a049"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01320a060"},{"key":"e_1_2_8_220_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/genetics\/163.1.79","article-title":"Genetic diversity in yeast assessed with whole\u2010genome oligonucleotide arrays","volume":"163","author":"Winzeler E. A.","year":"2003","journal-title":"Genetics"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi701172v"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1111\/1567-1364.12218"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.11.6845-6855.2005"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a133929"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a131338"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1804"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3847"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-12-3437"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081366"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.10608"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0061(20010315)18:4<325::AID-YEA669>3.0.CO;2-K"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101241"}],"container-title":["Yeast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fyea.3461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/yea.3461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/yea.3461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/yea.3461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:26:12Z","timestamp":1694024772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/yea.3461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":231,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/yea.3461"],"URL":"https:\/\/doi.org\/10.1002\/yea.3461","archive":["Portico"],"relation":{},"ISSN":["0749-503X","1097-0061"],"issn-type":[{"value":"0749-503X","type":"print"},{"value":"1097-0061","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,6]]},"assertion":[{"value":"2019-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}