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Since CYM inhibits cell growth, biomass production, and respiration in <jats:italic>Saccharomyces cerevisiae<\/jats:italic>, we used this model to characterize the effect of CYM on mitochondria. We found it inhibits oxygen consumption in both whole cells and isolated mitochondria, specifically inhibiting cytochrome <jats:italic>c<\/jats:italic> oxidase (C<jats:italic>c<\/jats:italic>O) activity during oxidative phosphorylation. Based on molecular docking, we propose that CYM blocks the interaction of cytochrome <jats:italic>c<\/jats:italic> with C<jats:italic>c<\/jats:italic>O, hampering electron transfer and inhibiting C<jats:italic>c<\/jats:italic>O catalytic activity. Although other targets cannot be excluded, our data offer valuable insights into the mode of action of CYM that will be instrumental in driving informed management of the use of this fungicide.<\/jats:p>","DOI":"10.1002\/1873-3468.14907","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T03:55:55Z","timestamp":1715831755000},"page":"1655-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The fungicide cymoxanil impairs respiration in <i>Saccharomyces cerevisiae via<\/i> cytochrome <i>c<\/i> oxidase inhibition"],"prefix":"10.1002","volume":"598","author":[{"given":"Filipa","family":"Mendes","sequence":"first","affiliation":[{"name":"CBMA \u2013 Centre of Molecular and Environmental Biology\/ARNET \u2013 Aquatic Research Network, Department of Biology, School of Sciences University of Minho  Braga 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