{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:33:20Z","timestamp":1725503600660},"edition-number":"1","reference-count":30,"publisher":"Wiley","isbn-type":[{"type":"print","value":"9780470016176"},{"type":"electronic","value":"9780470015902"}],"license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:label\/>\n            <jats:p>Genetic diseases are caused by amino acid replacements at functionally important positions of protein sequences. These positions are conserved at the interspecific level, indicating that their replacement would be expected to be deleterious between homologous sequences. However, several examples of human disease\u2010associated mutations have been found in the genomes of non\u2010human species. Following the model of compensatory evolution, the acceptability of human deleterious mutations in other species is strictly dependent on the presence of a compensatory partner variant that is able to compensate for the negative effect of the mutation. The co\u2010occurrence of a compensated mutation and its compensatory partner has now been documented for a large number of proteins involved in human genetic disease, thereby increasing theoretical and experimental support for the model of compensatory evolution at the same time as providing us with an improved understanding of the molecular and selective forces underlying the mechanism of amino acid interaction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Key Concepts<\/jats:title>\n            <jats:p>\n              <jats:list list-type=\"bullet\">\n                <jats:list-item>\n                  <jats:p>A high number of human disease\u2010associated mutations are found in non\u2010human species.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>Many human disease\u2010associated mutations are compensated in non\u2010human species by epistatic interactions with a compensatory variant.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>The deleterious impact of a variant depends on the genetic background where it occurs.<\/jats:p>\n                <\/jats:list-item>\n                <jats:list-item>\n                  <jats:p>The basis of molecular compensation results from the structural interaction between amino acid variants.<\/jats:p>\n                <\/jats:list-item>\n              <\/jats:list>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/9780470015902.a0022402","type":"other","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T06:10:33Z","timestamp":1424067033000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Compensatory Evolution in Disease\u2010Associated 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