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However, non\u2010methodical and inadequate sampling of the left ventricle often leads to misinterpretations and variability, making direct study comparisons unreliable. Protocols are provided for representative sampling of the ischemic mouse heart followed by morphometric analysis of the left ventricle. Extending the use of this sampling to other types of in situ analysis is also illustrated through the assessment of neovascularization and cellular engraftment in a cell\u2010based therapy setting. This is of interest to the general cardiovascular research community as it details methods for standardization and simplification of histo\u2010morphometric evaluation of emergent heart therapies. \u00a9 2015 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/9780470942390.mo140293","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T14:15:30Z","timestamp":1448979330000},"page":"359-391","source":"Crossref","is-referenced-by-count":4,"title":["Optimized Heart Sampling and Systematic Evaluation of Cardiac Therapies in Mouse Models of Ischemic Injury: Assessment of Cardiac Remodeling and Semi\u2010Automated Quantification of Myocardial Infarct Size"],"prefix":"10.1002","volume":"5","author":[{"given":"Mariana","family":"Valente","sequence":"first","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto  Porto Portugal"},{"name":"INEB \u2013 Instituto de Engenharia 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