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Cells of intermediate passages were grown on plastic\u2010coated, carbon\u2010shadowed gold grids, fixed with glutaraldehyde, post\u2010fixed with osmium tetroxide, stained with uranyl salts and critical\u2010point dried. The absence of an embedding matrix produces images of increased contrast and resolution.<\/jats:p><jats:p>The approach combined with stereo\u2010microscopy has extended our knowledge of cellular ultrastructure. Stereo\u2010images of whole cells reveal nuclei, mitochondria, microtubules, microfilaments, the endoplasmic reticulum and ribosomes in their expected forms. At high magnifications a continuity of microtubules, microfilaments and membranous elements with thin (3\u20136 nm) strands of the ground substance has been observed. These strands form a three\u2010dimensional lattice or mesh that pervades all parts of the cytoplasm. The entire structure is referred to as a microtrabecular lattice or mesh, the strands being the trabeculae. 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