{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:15:23Z","timestamp":1759331723162},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":10109,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoclasts have been observed for the first time in toothless (<jats:styled-content>tl<\/jats:styled-content>) rats, a mutation which inherits osteopetrosis as an autosomal recessive. The ability of <jats:styled-content>tl<\/jats:styled-content> rats to raise the serum calcium concentration after injection of parathyroid extract was severely limited when compared with normal littermates. In addition, osteopetrosis in <jats:styled-content>tl<\/jats:styled-content> rats is not cured by radiation and infusion of normal spleen or bone marrow cells from normal littermates, a method known to cure osteopetrosis in mutants of this and other species. This indirect evidence for a reduction in bone resorption as a cause of osteopetrosis in this mutation and the failure of transplanted cells to cure the disease are discussed in relation to the development and function of osteoclasts.<\/jats:p>","DOI":"10.1002\/aja.1001490212","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T13:29:26Z","timestamp":1109424566000},"page":"289-297","source":"Crossref","is-referenced-by-count":69,"title":["Osteopetrosis in the toothless (tl) rat: Presence of osteoclasts but failure to respond to parathyroid extract or to be cured by infusion of spleen or bone marrow cells from normal littermates"],"prefix":"10.1002","volume":"149","author":[{"suffix":"Jr.","given":"Sandy C.","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-146-38146"},{"key":"e_1_2_1_3_1","first-page":"B\u2010302","article-title":"Parathyroid hormone as a possible factor in osteopetrosis","volume":"55","author":"Cotton W. 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