{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:52:59Z","timestamp":1699797179801},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":8983,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Anat."],"published-print":{"date-parts":[[1980,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present electron microscopic cytochemical investigation was undertaken to characterize the alterations in the Golgi apparatus and GERL of rat parotid acinar cells during ethionine intoxication and recovery. Although the Golgi apparatus and GERL were reduced in size, and some broadening of the Golgi saccules occurred as the result of ethionine treatment, the relative localization of thiamine pyrophosphatase (TPPase) activity in the Golgi saccules, and acid phosphatase activity (AcPase) in GERL, remained unchanged. Shortly after ethionine treatment was stopped, a dramatic redistribution of enzyme activities was noted. Within the first 24 hours of recovery, the Golgi apparatus began to enlarge, and the content of secretory granules increased. By day 3 of recovery, cisternae morphologically identifiable as GERL and forming secretory granules possessed TPPase activity, while AcPase activity was virtually undetectable. After seven days of recovery, the Golgi apparatus and GERL appeared both morphologically and cytochemically normal. The enzyme modulation observed during recovery may be correlated with increased secretory granule production. Furthermore, the presence of TPPase activity in GERL and forming secretory granules lends support to the suggestion that GERL may be derived from the trans Golgi saccule.<\/jats:p>","DOI":"10.1002\/aja.1001580304","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T03:15:39Z","timestamp":1109474139000},"page":"275-284","source":"Crossref","is-referenced-by-count":11,"title":["Morphological and cytochemical alterations of the Golgi apparatus and GERL in rat parotid acinar cells during ethionine intoxication and recovery"],"prefix":"10.1002","volume":"158","author":[{"given":"Constance","family":"Oliver","sequence":"first","affiliation":[]},{"given":"Regina E.","family":"Auth","sequence":"additional","affiliation":[]},{"given":"Arthur R.","family":"Hand","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.28.2.277"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.39.2.299"},{"key":"e_1_2_1_4_1","first-page":"101a","article-title":"Cytochemical study of the Golgi apparatus, GERL and lysosomes in neurosecretory neurons from normal and NaCl\u2013treated mice","volume":"79","author":"Broadwell R. D.","year":"1978","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_5_1","volume-title":"Role of Peptides in Neuronal Function","author":"Broadwell R. D.","year":"1980"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.72.1.1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00808388"},{"key":"e_1_2_1_8_1","first-page":"601","article-title":"Cytochemical studies of the Golgi apparatus and GERL in parotid acinar cells of developing rats","volume":"28","author":"Doine A. I.","year":"1980","journal-title":"J. Histochem. Cytochem"},{"key":"e_1_2_1_9_1","unstructured":"Doine A. I. C. Oliver andA. R.Hand(1980b)Cytochemical studies of the Golgi apparatus and GERL in rat parotid acinar cells at early postnatal periods. European J. Cell Biol. In Press (abstract)."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.73.2.366"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90055-6"},{"key":"e_1_2_1_12_1","volume-title":"Microscopic histochemistry: Principles and practice","author":"Gomori G.","year":"1952"},{"key":"e_1_2_1_13_1","first-page":"3041","article-title":"Functional and structural alterations of liver ergastoplasmic membranes during DL\u2010ethionine hepatocarcinogenesis","volume":"35","author":"Gravela E.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001300203"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001350107"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002972"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.74.2.399"},{"key":"e_1_2_1_18_1","unstructured":"Hand A. R.andC. Oliver(1980)Effects of Secretory Stimulation on the Golgi Apparatus and GERL of Rat Parotid Acinar Cells. J. Cell Biol. In Press (abstract)"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.39.3.589"},{"key":"e_1_2_1_20_1","first-page":"137a","article-title":"A formaldehyde\u2010glutaraldehyde fixative of high osmolality for use in electron microscopy","volume":"27","author":"Karnovsky M. J.","year":"1965","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236721"},{"key":"e_1_2_1_22_1","first-page":"3421","article-title":"A microsomal membrane alteration following ethionine intoxication","volume":"34","author":"Kisilevsky R.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001420104"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)91387-6"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90591-7"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(75)90569-8"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF02889329","article-title":"Degeneration of mouse pancreatic acinar cells during fasting","volume":"15","author":"Nevalainen T. J.","year":"1974","journal-title":"Virch. Arch. Abt. B Zellpath."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470715314.ch2"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.8.2781"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.47.6.802"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.75.1.148"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001550204"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.79.1.45"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.79.1.59"},{"key":"e_1_2_1_35_1","first-page":"371a","article-title":"Reversible alterations in the morphology of the Golgi complex induced by the arrest of secretory transport","volume":"75","author":"Palade G. E.","year":"1977","journal-title":"J. Cell Biol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.73.3.578"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(69)90338-5"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(69)90033-1"},{"key":"e_1_2_1_40_1","first-page":"369","article-title":"Biochemical basis for ethionine effects on tissue","volume":"25","author":"Stekol J. A.","year":"1963","journal-title":"Adv. Enzymol."},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1500335"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209038"},{"key":"e_1_2_1_43_1","first-page":"230","article-title":"Salivary gland regeneration after DL\u2010ethionine poisoning","volume":"20","author":"Ulmansky M.","year":"1969","journal-title":"Lab. Invest."},{"key":"e_1_2_1_44_1","first-page":"249","article-title":"Ethionine induced changes in salivary glands","volume":"17","author":"Ulmansky M.","year":"1967","journal-title":"Lab. Invest."},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0021-9258(18)81133-4","article-title":"The role of adenosine triphosphate deficiency in ethionine induced inhibition of protein synthesis","volume":"238","author":"Villa\u2010Trevino S.","year":"1963","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_46_1","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1016\/S0021-9258(18)99698-5","article-title":"The inhibition of liver ribonucleic acid synthesis by ethionine","volume":"241","author":"Villa\u2010Trevino S.","year":"1966","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.12.2.313"},{"key":"e_1_2_1_48_1","volume-title":"Cell Biology Monographs","author":"Whaley W. G.","year":"1975"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.57.2.406"},{"key":"e_1_2_1_50_1","first-page":"31","article-title":"Studies on early biochemical changes in female rat liver after administration of ethionine","volume":"22","author":"Yoshitsugu M.","year":"1971","journal-title":"Yokohama Medical Bulletin"}],"container-title":["American Journal of Anatomy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faja.1001580304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aja.1001580304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T02:34:35Z","timestamp":1698892475000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aja.1001580304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,7]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,7]]}},"alternative-id":["10.1002\/aja.1001580304"],"URL":"https:\/\/doi.org\/10.1002\/aja.1001580304","archive":["Portico"],"relation":{},"ISSN":["0002-9106","1553-0795"],"issn-type":[{"value":"0002-9106","type":"print"},{"value":"1553-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,7]]}}}