{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:12:48Z","timestamp":1776280368035,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":4933,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Med. Genet."],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fragile X [fraX] syndrome is a common hereditary disorder associated with a fragile site marker at Xq27.3 which clinically presents as a form of mental retardation (MR). Postmortem investigation of 3 fraX positive males with mild to moderate MR did not document any gross neuropathological changes. Golgi analysis of neocortical dendritic spine morphology extended our previous observations of immature, long, tortuous spines in one adult case of fraX (Rudelli, et al., <jats:italic>Acta Neuropathologica<\/jats:italic> 67:289\u2013295, 1985) to 2 new cases. Evidence for similar dendritic spine abnormalities was found, although Golgi analysis was less than optimal because of incomplete dendritic stain impregnation. Neocortical intra\u2010layer cell density was also investigated in all 3 cases. Cresyl violet stained neurons were counted in 10 randomly selected fields in neocortical layers II\u2013VI of cingulate and temporal association areas (Brodmann's areas 23 and 38). Neuron counts in fraX and control neocortex showed no significant differences. Thus, abnormal dendritic spine morphology with preservation of neuronal density appears to characterize the neocortex in individuals with this common form of mental retardation.<\/jats:p>","DOI":"10.1002\/ajmg.1320410306","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T03:47:06Z","timestamp":1118548026000},"page":"289-294","source":"Crossref","is-referenced-by-count":412,"title":["Analysis of neocortex in three males with the fragile X syndrome"],"prefix":"10.1002","volume":"41","author":[{"given":"V. J.","family":"Hinton","sequence":"first","affiliation":[]},{"given":"W. T.","family":"Brown","sequence":"additional","affiliation":[]},{"given":"K.","family":"Wisniewski","sequence":"additional","affiliation":[]},{"given":"R. D.","family":"Rudelli","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070512"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531375"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb40329.x"},{"key":"e_1_2_1_5_1","first-page":"43","volume-title":"Curative Aspects of Mental Retardation","author":"Caviness VS","year":"1983"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805263182102"},{"key":"e_1_2_1_7_1","first-page":"1330","article-title":"Cerebellar structure in autism","volume":"141","author":"Gaffney GR","year":"1987","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_8_1","first-page":"454","article-title":"Normal relative areas of the cerebellar vermis lobules I through V, compared with VI and VII and VIII","volume":"26","author":"Gingold M","year":"1989","journal-title":"Ann Neurol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230128"},{"key":"e_1_2_1_10_1","unstructured":"HintonVJ BrownWT RudelliRD: (1989): Morphometric analysis of neocortex in three males with the fragile X syndrome. 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