{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:04:59Z","timestamp":1772921099777,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,28]],"date-time":"2005-04-28T00:00:00Z","timestamp":1114646400000},"content-version":"vor","delay-in-days":12781,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Phys Anthropol"],"published-print":{"date-parts":[[1970,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An investigation of the founder effect has been made on the H\u2010leut, a religious isolate. Ninety\u2010one founders, representing a maximum of 150 independent genomes, have been shown to account for the total gene pool of the 9,536 people in two of the three major subpopulations within the isolate, the S\u2010leut and the L\u2010leut. Each of these two leut is subdivided into four clans which in turn are subdivided into colonies. Mal\u00e9cot's coefficient of kinship has been calculated between each of the 91 founders and the contemporary parents, and used to describe the relative genetic contributions of the founders to the gene pool of each subpopulation. Analysis of this distribution suggests that a considerable amount of genetic diversity may be attributable to the founder effect. Part of this diversity may be accounted for by variation in the birth dates of the founders. The size of the subset of the 91 founders related to each subpopulation decreases with decreasing subpopulation level. A correlation has been found between two measures of relationship between pairs of clans: (1) Kurczynski's modification of Mahalanobis's distance measure based on gene frequency differences; and (2) a comparison of the relative contributions of founders to the gene pools of the clans.<\/jats:p>","DOI":"10.1002\/ajpa.1330320305","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T16:53:06Z","timestamp":1123519986000},"page":"351-367","source":"Crossref","is-referenced-by-count":46,"title":["The founder effect in a human isolate: Evolutionary implications"],"prefix":"10.1002","volume":"32","author":[{"given":"Alice O.","family":"Martin","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,4,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.5.1252"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1950.015.01.028"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/2406029"},{"key":"e_1_2_1_5_1","unstructured":"Bleibtreu H. K.1964Marriage and residence patterns in a genetic isolate. Ph.D. thesis. Harvard University."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1964.029.01.006"},{"key":"e_1_2_1_7_1","first-page":"206","article-title":"Social biology of very high fertility","volume":"25","author":"Eaton J. W.","year":"1953","journal-title":"Hum. Biol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1834-4453.1966.tb00012.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb43053.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)60128-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330140402"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a070670"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1963.tb01335.x"},{"key":"e_1_2_1_14_1","unstructured":"Kurczynski T. W.1969Studies of genetic drift in a human isolate. Ph.D. thesis. Case\u2010Western Reserve University."},{"key":"e_1_2_1_15_1","unstructured":"Malecot G.1948Les Mathematiques de Theredite Masson et Cie Paris."},{"key":"e_1_2_1_16_1","volume-title":"The Fifth Berkeley Symposium on Probability and Statistics","author":"Malecot G.","year":"1968"},{"key":"e_1_2_1_17_1","unstructured":"Mange A. P.1963The population structure of a human isolate. Ph.D. thesis. University of Wisconsin."},{"key":"e_1_2_1_18_1","first-page":"104","article-title":"Growth and inbreeding of a human isolate","volume":"36","author":"Mange A. P.","year":"1964","journal-title":"Hum. Biol."},{"key":"e_1_2_1_19_1","first-page":"484","article-title":"Fortran programs for computing Wright's coefficient of inbreeding in human and nonhuman pedigrees","volume":"16","author":"Mange A. P.","year":"1964","journal-title":"Am. J. Hum. Gen."},{"key":"e_1_2_1_20_1","unstructured":"Martin A. O.1969Recurrent founder effect in a human isolate: history and genetic consequences. Ph.D. thesis. Case\u2010Western Reserve University."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-1112.2004.00433.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1964.029.01.015"},{"key":"e_1_2_1_23_1","first-page":"554","article-title":"Some hypotheses\u2010generalizations resulting from these studies. In: Further Studies on the Xavante Indians","volume":"19","author":"Neel J. V.","year":"1967","journal-title":"Amer. J. Hum. Gen."},{"key":"e_1_2_1_24_1","volume-title":"All Things Common: the Hutterian Way of Life","author":"Peters V. J.","year":"1965"},{"key":"e_1_2_1_25_1","first-page":"494","article-title":"Genetic fitness in a colonizing human population","volume":"40","author":"Roberts D. F.","year":"1968","journal-title":"Hum. 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