{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:12Z","timestamp":1762067112906},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":10021,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An in vitro preparation has been developed in which epileptogenesis in mammalian central nervous system tissue may be studied. Addition of sodium penicillin to the medium bathing slices of guinea pig hippocampus induced epileptiform activity similar to that seen in hippocampal penicillin foci in vivo. Epileptiform events were recorded as synchronous field potentials and correlated cellular bursts that ocurred spontaneously and could be triggered by orthodromic stimulation. Intracellular recordings revealed that bursts were generated from large depolarization shifts in some neurons, while in others, burst discharges had little underlying baseline depolarization. This finding, and the presence of fast prepotentials in penicillin\u2010treated preparations, suggested the involvement of dendritic activity in generation of epileptiform discharges.<\/jats:p>","DOI":"10.1002\/ana.410010510","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:18:52Z","timestamp":1104538732000},"page":"463-469","source":"Crossref","is-referenced-by-count":178,"title":["Penicillin\u2010induced epileptiform activity in the hippocampal in vitro preparation"],"prefix":"10.1002","volume":"1","author":[{"given":"Philip A.","family":"Schwartzkroin","sequence":"first","affiliation":[]},{"given":"David A.","family":"Prince","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(64)90001-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(70)90066-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3974.915"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90159-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90237-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90662-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90817-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(72)90066-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90038-2"},{"key":"e_1_2_1_11_2","volume-title":"Effects of pentyleneterazol and picrotoxin on hippocampal slices in vitro","author":"Hori N","year":"1974"},{"key":"e_1_2_1_12_2","volume-title":"Epileptogenesis in mammalian cortex studied in vitro","author":"Schwartzkroin PA","year":"1976"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234086"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.5.649"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(64)90025-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.5.688"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90066-6"},{"key":"e_1_2_1_18_2","unstructured":"SchwartzkroinPA: Further characteristics of hippocampal CA1 cellsin vitro.Brain Res(in press)"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1152\/jn.1961.24.3.272","article-title":"Electrophysiology of hippocampal neurons: IV. 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