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Central nervous system complications were of four kinds: (1) Infections included <jats:italic>Toxoplasma gondii<\/jats:italic> abscesses in 5 patients, progressive multifocal leukoencephalopathy in 2, cryptococcal meningitis in 2, <jats:italic>Candida albicans<\/jats:italic> in 1, and possible <jats:italic>Mycobacterium avium intracellulare<\/jats:italic> in 3. Eighteen patients suffered a subacute encephalitis possibly attributable to cytomegalovirus infection. (2) Tumors consisted of primary lymphoma of the brain in 3 patients and meningeal invasion by systemic lymphoma in 4. (3) Vascular complications included nonbacterial thrombotic endocarditis in 2 patients and cerebral hemorrhages in the setting of thrombocytopenia in 3. (4) Undiagnosed central nervous system problems were evidenced as focal brain lesions in 3 patients and self\u2010limiting aseptic meningitis in 4. 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