{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:39:54Z","timestamp":1772764794811,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":5652,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple factors have been hypothesized over the years to be contributory and\/or causative for Parkinson's disease (PD). Hereditary factors, although originally discounted, have recently emerged in the focus of PD research. The study of a large Italian family with PD using a genome scan approach led to the mapping of a PD susceptibility gene to the 4q21\u2013q23 genomic region, where the gene for \u03b1\u2010synuclein was previously mapped. Mutation analysis of the \u03b1\u2010synuclein in four unrelated families with PD revealed a missense mutation segregating with the illness. \u03b1\u2010Synuclein is an abundant presynaptic protein in the human brain with unknown function. It is conceivable that the mutation identified in the PD families may result in self\u2010aggregation and\/or decreased degradation of the protein, leading to the development of intracytoplasmic inclusion bodies and eventually to neuronal cell death. Moreover, the discovery of a mutation in the synuclein gene may offer us new insights in the understanding of the pathways that lead to neuronal degeneration.<\/jats:p>","DOI":"10.1002\/ana.410440710","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T10:38:31Z","timestamp":1393065511000},"source":"Crossref","is-referenced-by-count":48,"title":["Autosomal dominant parkinson's disease and \u03b1\u2010synuclein"],"prefix":"10.1002","volume":"44","author":[{"given":"Mihael H.","family":"Polymeropoulos","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410440710","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410440710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:07:44Z","timestamp":1695802064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410440710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1002\/ana.410440710"],"URL":"https:\/\/doi.org\/10.1002\/ana.410440710","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}