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This property allows these enzymes to be used for the systematic fragmentation of DNA molecules in structural and functional analyses of genetic material. The biological function of restriction endonucleases could be to provide a sort of primitive immune system which enables the cells to destroy foreign genetic material. Methylation of nucleotides lying within the recognition sequence serves to protect the cell's own DNA from being degraded by its restriction endonucleases. Restriction endonucleases were discovered during the investigation of the restriction of viral growth observed on changing hosts.<\/jats:p>","DOI":"10.1002\/anie.197800733","type":"journal-article","created":{"date-parts":[[2003,12,31]],"date-time":"2003-12-31T13:47:35Z","timestamp":1072878455000},"page":"73-79","source":"Crossref","is-referenced-by-count":32,"title":["Restriction Endonucleases"],"prefix":"10.1002","volume":"17","author":[{"given":"Werner","family":"Arber","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2003,12,22]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.64.4.557-569.1952"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.65.2.113-121.1953"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/170492b0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-80-19575"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(62)80058-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(62)80059-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(65)80055-9"},{"key":"e_1_2_1_8_2","first-page":"295","volume":"18","author":"Arber W.","year":"1968","journal-title":"Symp. 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