{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:09:29Z","timestamp":1760980169105},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":15405,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anat. Rec."],"published-print":{"date-parts":[[1962,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Golgi apparatus has been recognized as the initial site of mucigen accumulation. The mucigen is seen forming within the agranular lamellar membranes and vesicles of the Golgi, enlarging and coalescing with loss of individual mucigen droplet membranes, bulging the cell into its characteristic goblet appearance, and subsequent rupturing of the microvilli plasma membrane with discharge of the mucin. The density of the well developed goblet cell is a function of nuclear and cytoplasmic compression by the mass of mucigen. The fine structure of the \u201cresting goblet\u201d cell is indistinguishable from that of the principal columnar absorbing cells. No morphologic evidence of mucigen formation in the endoplasmic reticulum is found, but continuity is demonstrated between the rough\u2010surfaced endoplasmic reticulum and agranular Golgi membranes. It is possible that the mucigen or its precursors may be synthesized in the endoplasmic reticulum then transported to the Golgi where it is concentrated into the morphologically recognizable mucigen.<\/jats:p>","DOI":"10.1002\/ar.1091440406","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T09:43:23Z","timestamp":1109411003000},"page":"341-357","source":"Crossref","is-referenced-by-count":58,"title":["Fine structure of the goblet cell mucous secretory process"],"prefix":"10.1002","volume":"144","author":[{"given":"James A.","family":"Freeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1962.tb01752.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000330203"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.1.4.287"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.10.1.37"},{"key":"e_1_2_1_6_1","first-page":"256","article-title":"Beitrage zur kenntnisdes vogeldarmes. V. Teil. Die Schleimbildung im darnepithel mit besonderer ber\u00fccksichtigung der becherzellenfrage","volume":"6","author":"Clara M.","year":"1926","journal-title":"Ztschr. F. Mikr. Anat."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/BF00347683","article-title":"A study of the Golgi material of hepatic and intestinal epithelial cells with the electron microscope","volume":"36","author":"Dalton A.","year":"1952","journal-title":"Ztschr. Zellforsch."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000920204"},{"key":"e_1_2_1_9_1","first-page":"274","volume-title":"Fine Structure of Cells","author":"Dalton A.","year":"1955"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1960.sp001487"},{"key":"e_1_2_1_11_1","first-page":"179","volume-title":"General Pathology","author":"Florey H.","year":"1962"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.13.3.437"},{"key":"e_1_2_1_13_1","first-page":"27","article-title":"L'appareil de Golgi dans les cellules normales et canc\u00e9reuses des vert\u00e9br\u00e9s","volume":"44","author":"Hagenau F.","year":"1955","journal-title":"Arch. Anat. Mic."},{"key":"e_1_2_1_14_1","first-page":"103","article-title":"Beitr\u00e4ge zur histologic und physiologie der d\u00fcnndarmschleimhaut","volume":"43","author":"Heidenhain R.","year":"1888","journal-title":"Pfl\u00fcgers Arch. F. d. ges. Physiol. (suppl. z. bd.)"},{"key":"e_1_2_1_15_1","first-page":"195","volume-title":"Biologic Structure and Function","author":"Hirsch G.","year":"1961"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1956.sp001171"},{"key":"e_1_2_1_17_1","first-page":"253","volume-title":"Special Cytology","author":"Macklin C.","year":"1932"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60462-3"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977833"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62726-6"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.1.1.59"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.1.6.567"},{"key":"e_1_2_1_23_1","first-page":"305","volume-title":"Frontiers in Cytology","author":"Palay S.","year":"1958"},{"key":"e_1_2_1_24_1","first-page":"964","article-title":"Ultrastructure of the tracheal ciliated mucosa in rat and man","volume":"68","author":"Rhodin J.","year":"1959","journal-title":"Ann. Otol."},{"key":"e_1_2_1_25_1","first-page":"164","article-title":"Das dr\u00fcsenepithel der schlauchf\u00f6rmigen dr\u00fcssen des dunnund dickdarmes und die becherzellen","volume":"161","author":"Schulze F.","year":"1886","journal-title":"Vorl. Mitt. Zentrabl. d. Med. Wiss."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001040106"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1960.sp001488"},{"key":"e_1_2_1_28_1","first-page":"434","article-title":"Observations on the ultrastructure of the goblet cells of the rat duodenum","volume":"133","author":"Taylor J.","year":"1959","journal-title":"Anat. Rec."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.101.2.213"}],"container-title":["The Anatomical Record"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Far.1091440406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ar.1091440406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:38:45Z","timestamp":1699771125000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ar.1091440406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1962,12]]}},"alternative-id":["10.1002\/ar.1091440406"],"URL":"https:\/\/doi.org\/10.1002\/ar.1091440406","archive":["Portico"],"relation":{},"ISSN":["0003-276X","1097-0185"],"issn-type":[{"value":"0003-276X","type":"print"},{"value":"1097-0185","type":"electronic"}],"subject":[],"published":{"date-parts":[[1962,12]]}}}