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By the appropriate injection schedules of H<jats:sup>3<\/jats:sup>\u2010thymidine and by varying the postinjection interval, it is possible to essentially confine the label to one or the other of the populations. Thus two groups of animals were administered H<jats:sup>3<\/jats:sup>\u2010thymidine so that in one group only long\u2010lived small lymphocytes were labeled and in the other, short\u2010lived lymphocytes were labeled. The animals were then injected intraperitoneally with 4 mg doses of hydrocortisone at four\u2010hour intervals. Controls were administered saline. At intervals after receiving from 1 to 12 hydrocortisone injections, the animals were sacrificed and radioautographs were prepared of the thymus, thoracic duct lymph, mesenteric lymph node, bone marrow and spleen. These are tissues known to show significant differences with respect to the percentage distribution of long\u2010 and short\u2010lived lymphocytes.<\/jats:p><jats:p>The results from analyzing the percentages of labeled small lymphocytes present in the respective tissues of the two groups are believed to be conclusive in showing that short\u2010lived small lymphocytes are more susceptible to the destructive effects of hydrocortisone than are the long\u2010lived lymphocytes.<\/jats:p>","DOI":"10.1002\/ar.1091620309","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T23:25:13Z","timestamp":1109460313000},"page":"349-356","source":"Crossref","is-referenced-by-count":27,"title":["The differential effect of hydrocortisone on the short\u2010lived small lymphocyte"],"prefix":"10.1002","volume":"162","author":[{"given":"Jose N.","family":"Esteban","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-73-17648"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1956.tb01707.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/202714a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207257"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000204948"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.125.6.1149"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1952.32.4.379"},{"key":"e_1_2_1_9_1","first-page":"305","volume-title":"The Mechanism of Inflammation, An International Symposium","author":"Craddock C. 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