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An intracellular formaldehyde\u2010induced fluorescent substance was identified as serotonin by microspectrofluorometric techniques. Fluorescence microscopy and subsequent histochemical staining of the same sections demonstrated that serotonin\u2010containing cells were argentaffin\u2010, argyrophil\u2010, and ferric ferricyanide\u2010positive. The serotonin\u2010containing epithelial cells were more numerous in ventral than in dorsal aspects of trachea. The number of detectable fluorescent cells was reduced after reserpine administration but was not affected by injecting the amine precursor L\u2010dihydroxyphenylalanine (L\u2010DOPA). The emission peak of the fluorophore was not significantly shifted after L\u2010DOPA injections. The cells may regulate tracheobronchial\u2010pulmonary function by releasing serotonin or other as yet unidentified biologically active substances.<\/jats:p>","DOI":"10.1002\/ar.1091990104","type":"journal-article","created":{"date-parts":[[2005,2,27]],"date-time":"2005-02-27T00:02:40Z","timestamp":1109462560000},"page":"23-31","source":"Crossref","is-referenced-by-count":29,"title":["Morphology, histochemistry, and distribution of serotonin\u2010containing cells in tracheal epithelium of adult rabbit"],"prefix":"10.1002","volume":"199","author":[{"given":"Richard D.","family":"Dey","sequence":"first","affiliation":[]},{"given":"Robert","family":"Echt","sequence":"additional","affiliation":[]},{"given":"Robert J.","family":"Dinerstein","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,2,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-49204-4_17"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rklund A. B.Falck andR.H\u00e5kanson(1968)Histochemical demonstration of tryptamine properties of the formaldehyde\u2010induced fluorophores of tryptamine and related indole compounds in models. Acta Physiol. Scand. Suppl. 318.","DOI":"10.1111\/j.1748-1716.1968.tb04318.x"},{"key":"e_1_2_1_4_1","first-page":"318","volume-title":"Methods in Investigative and Diagnostic Endocrinology: The Biogenic Amines","author":"Bj\u00f6rklund A.","year":"1972"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00268031"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15.2.65"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/12.8.582"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091730110"},{"key":"e_1_2_1_9_1","first-page":"458","article-title":"Endocrine cells in rat fetal lungs","volume":"30","author":"Cutz E.","year":"1974","journal-title":"Lab. 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