{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:21:57Z","timestamp":1776316917890,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":11405,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis &amp; Rheumatism"],"published-print":{"date-parts":[[1974,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The serum urate\u2010lowering effect of probenecid was used to monitor compliance in a placebo\u2010controlled study of prophylactic colchicine therapy for intercritical gout. Although all patients included in the analysis had satisfactory control of hyperuricemia, 20 patients receiving 1.5 mg of colchicine daily averaged 2.3 attacks of acute gout per year of therapy, compared to 18 placebo\u2010treated patients who averaged 6 attacks per year (P &lt; 0.05), confirming the effectiveness of prophylactic colchicine in this situation.<\/jats:p>","DOI":"10.1002\/art.1780170517","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T16:30:19Z","timestamp":1171470619000},"page":"609-614","source":"Crossref","is-referenced-by-count":93,"title":["Prophylactic colchicine therapy of intercritical gout. A placebo\u2010controlled study of probenecid\u2010treated patients"],"prefix":"10.1002","volume":"17","author":[{"given":"Harold E.","family":"Paulus","sequence":"first","affiliation":[]},{"given":"Lee H.","family":"Schlosstein","sequence":"additional","affiliation":[]},{"given":"Robert G.","family":"Godfrey","sequence":"additional","affiliation":[]},{"given":"James R.","family":"Klinenberg","sequence":"additional","affiliation":[]},{"given":"Rodney","family":"Bluestone","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780080502"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193610000-00006"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1953.03690120022006"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.62980150007010"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90374-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-55-2-179"},{"key":"e_1_2_1_8_2","first-page":"663","article-title":"The failure of uricosuric drugs to reduce the attack rate in primary non\u2010tophaceous gout","volume":"12","author":"Gaines LM","year":"1969","journal-title":"Arthritis Rheum"},{"key":"e_1_2_1_9_2","first-page":"903","article-title":"The enzymatic spectrophotometric method for determination of uric acid","volume":"54","author":"Liddle L","year":"1959","journal-title":"J Lab Clin Med"}],"container-title":["Arthritis &amp; Rheumatism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fart.1780170517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/art.1780170517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:33:45Z","timestamp":1700696025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/art.1780170517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,9]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1974,9]]}},"alternative-id":["10.1002\/art.1780170517"],"URL":"https:\/\/doi.org\/10.1002\/art.1780170517","archive":["Portico"],"relation":{},"ISSN":["0004-3591","1529-0131"],"issn-type":[{"value":"0004-3591","type":"print"},{"value":"1529-0131","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,9]]}}}