{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:40:55Z","timestamp":1767008455967},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":9833,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The exchange rate of the indole nitrogen proton with solvent water protons was measured as a function of pH and temperature for tryptophan, <jats:italic>N<\/jats:italic>\u2010methyl tryptophan, glycyl tryptophan, tryptophanamide, tryptophylglycine, and tryptophylglycyl glycine. The nmr observation was by long\u2010pulse Fourier transform methods, and kinetics were inferred from saturation recovery, H<jats:sub>2<\/jats:sub>O transfer of saturation, and linewidth. There are observable differences between the rates of these compounds, but all are describable within a factor of two by specific acid and base\u2010catalyzed rates <jats:italic>k<\/jats:italic><jats:sub>H<\/jats:sub> = 100 and <jats:italic>k<\/jats:italic><jats:sub>OH<\/jats:sub> = 10<jats:sup>8<\/jats:sup> 1\/mol\u2010sec at 27\u00b0C. It is concluded that this behaviour is representative of this proton on the indole side chain in a random\u2010chain peptide exposed to water.<\/jats:p>","DOI":"10.1002\/bip.1977.360160311","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T01:07:54Z","timestamp":1104368874000},"page":"623-629","source":"Crossref","is-referenced-by-count":32,"title":["Nuclear magnetic resonance studies of exchangeable protons. II. The solvent exchange rate of the indole nitrogen proton of tryptophan derivatives"],"prefix":"10.1002","volume":"16","author":[{"given":"Susan F.","family":"Waelder","sequence":"first","affiliation":[]},{"given":"Alfred G.","family":"Redfield","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00745a035"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(75)90035-9"},{"key":"e_1_2_1_4_2","volume-title":"NMR: Basic Principles and Progress","author":"Redfield A. G.","year":"1976"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00843a066"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1592-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01072a040"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)99364-5"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbip.1977.360160311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.1977.360160311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T06:56:50Z","timestamp":1699772210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.1977.360160311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["10.1002\/bip.1977.360160311"],"URL":"https:\/\/doi.org\/10.1002\/bip.1977.360160311","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"value":"0006-3525","type":"print"},{"value":"1097-0282","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]}}}