{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:22:47Z","timestamp":1773289367652,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":11780,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[1971,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Equations are developed to describe the shift in the temperature of the helix\u2013coil transition when small molecules bind to nucleic acids. Included are high polymers, oligonucleotides, and oligomer\u2013polymer interactions. The equations prescribe simple ways of plotting experimental data to evaluate transition and binding parameters.<\/jats:p>","DOI":"10.1002\/bip.360101110","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T12:11:58Z","timestamp":1104322318000},"page":"2147-2160","source":"Crossref","is-referenced-by-count":190,"title":["Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria"],"prefix":"10.1002","volume":"10","author":[{"given":"Donald M.","family":"Crothers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00268976000100431"},{"key":"e_1_2_1_3_2","first-page":"230","volume":"29","author":"Schellman J. A.","year":"1955","journal-title":"Compt. Rend. Trav. Lab. Carlsberg, Ser. Chim."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030490418"},{"key":"e_1_2_1_5_2","first-page":"417","volume-title":"Biological Macromolecules","author":"von Hippel P. H.","year":"1969"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1970.360091102"},{"key":"e_1_2_1_7_2","volume-title":"Conformation of Macromolecules","author":"Birshtein T. M.","year":"1966"},{"key":"e_1_2_1_8_2","first-page":"294","volume":"8","author":"Sukhorukov B. I.","year":"1963","journal-title":"Biofizika"},{"key":"e_1_2_1_9_2","first-page":"362","volume":"7","author":"Permogorov V. I.","year":"1965","journal-title":"Vysokomol. Soedin."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1970.360090309"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1969.360080502"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1969.360070402"},{"key":"e_1_2_1_13_2","unstructured":"D.Hennage Thesis Yale University New Haven Conn. 1969."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1968.360060407"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1968.360060406"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1968.360061208"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(66)80183-3"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(66)80189-4"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1697082"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360010204"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1730390"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1725077"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1731411"},{"key":"e_1_2_1_24_2","unstructured":"V.Bloomfield D. M.Crothers andI.Tinoco Physical Chemistry of Nucleic Acids Harper & Row in press."},{"key":"e_1_2_1_25_2","unstructured":"D. W.HennageandD. M.Crothers paper in preparation."},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1727787"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1965.360030410"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(70)90399-2"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100866a080"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbip.360101110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.360101110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T09:57:33Z","timestamp":1699783053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.360101110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1971,11]]}},"alternative-id":["10.1002\/bip.360101110"],"URL":"https:\/\/doi.org\/10.1002\/bip.360101110","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"value":"0006-3525","type":"print"},{"value":"1097-0282","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,11]]}}}