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Analysis of the ratio of transported protein in the two optic tracts provides a new and useful assay of the degree of decussation in experimental animals. The effects of the mutations on eye pigmentation, whole eye melanin content and relative tyrosinase activity also were examined. The degree of ipsilateral innervation generally correlates with the degree of pigmentation of the retinal pigment epithelium and with tyrosinase activity. However, discrepancies have been found in c<jats:sup>h<\/jats:sup> and c<jats:sup>e<\/jats:sup> mutants. In these animals the pigment epithelium is well pigmented, and the area of ipsilateral innervation in the lateral geniculate nucleus is extensive, despite a high ratio of label in contralateral to ipsilateral optic tracts and low tyrosinase activity. Furthermore, mice heterozygous for the c<jats:sup>2J<\/jats:sup> allele have pigmentation and optic projections that are normal even though tyrosinase is reduced to 40% of normal. The few anomalous results suggest that alternative or additional factors may control optic axon projections.<\/jats:p>","DOI":"10.1002\/cne.901820304","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T18:29:34Z","timestamp":1104604174000},"page":"399-421","source":"Crossref","is-referenced-by-count":128,"title":["Genetic control of retinal ganglion cell projections"],"prefix":"10.1002","volume":"182","author":[{"given":"Jennifer H.","family":"Lavail","sequence":"first","affiliation":[]},{"given":"Ralph A.","family":"Nixon","sequence":"additional","affiliation":[]},{"given":"Richard L.","family":"Sidman","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90169-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.2.247"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(62)90337-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90344-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0031577"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901660406"},{"key":"e_1_2_1_8_1","first-page":"430","article-title":"Asymmetric visually evoked potentials in human albinos: Evidence for visual system anomalies","volume":"13","author":"Creel D.","year":"1974","journal-title":"Invest. 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