{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:56:11Z","timestamp":1783702571428,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,9]],"date-time":"2004-10-09T00:00:00Z","timestamp":1097280000000},"content-version":"vor","delay-in-days":9262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Comparative Neurology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The histogenesis, the time of origin and the pattern of migration of the cells in the hippocampus and dentate gyrus, have been studies in normal and reeler mice.<\/jats:p><jats:p>The earliest indication of a defect in the reeler hippocampus is seen on the fifteenth embryonic day (E15) which is at least 24 hours after the first indication of a defect in the neocortex. It is not until E18, that the dentate gyrus shows signs of its incipient abnormality. It appears then, in both the hippocampus and the dentate gyrus the gene defect first manifests itself at the stage at which the definitive cellular are assembled. Experiments involving the injection of <jats:sup>3<\/jats:sup>(H\u2010TdR) at different developmental stages have confirmed that the site and rate of cellular proliferation in the reeler hippocampus and dentate gyrus are normal, as is the initial pattern of cell migration. However, in the reeler dentate gyrus, most postnatal cell proliferation occurs ectopically and in the hippocampus the normal \u201cinside\u2010out\u201d sequence of neurogenesis is reversed, the earliest pyramidal cells generated coming to lie superficially within the <jats:italic>stratum pyramidale<\/jats:italic> and the later formed cells being added at progressively deeper levels. There is no discernible gradient in the time of origin of the granule cells in the radial dimension of the reeler dentate gyrus, whereas there is an obvious \u201coutside\u2010in\u201d gradient in the normal animal. The characteristic gradients in cell proliferation seen in the transverse and longitudinal dimensions of the normal dentate gyrus are, however, also evident in the reeler mouse. Taken together, these observations suggest that the reeler gene exerts its effect on neuronal position only in the radial dimension, and does so at a stage of development subsequent to the proliferation and initial migration of the relevant neurons.<\/jats:p><jats:p>Timm's sulfide silver preparations indicate that the characteristic staining patterns seen in the dentate gyrus and hippocampus appear at the same time, and mature at the same rate in normal and reeler mice.<\/jats:p>","DOI":"10.1002\/cne.901850303","type":"journal-article","created":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T19:56:24Z","timestamp":1104263784000},"page":"423-459","source":"Crossref","is-referenced-by-count":197,"title":["The development of the hippocampus and dentate gyrus in normal and reeler mice"],"prefix":"10.1002","volume":"185","author":[{"given":"Brent B.","family":"Stanfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Maxwell","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901280404"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901260302"},{"key":"e_1_2_1_5_1","first-page":"201","article-title":"Autoradiographic study of histogenesis in the hippocampal formation of the mouse","volume":"145","author":"Angevine J. B.","year":"1963","journal-title":"Anat. Rec."},{"key":"e_1_2_1_6_1","first-page":"255","article-title":"Autoradiographic study of histogenesis in the area dentata of the cerebral cortex in the mouse","volume":"148","author":"Angevine J. B.","year":"1964","journal-title":"Anat. Rec."},{"key":"e_1_2_1_7_1","first-page":"1","article-title":"Time of origin in the hippocampal region. An autoradiographic study in the mouse","volume":"2","author":"Angevine J. B.","year":"1965","journal-title":"Exptl. Neurol. Suppl."},{"key":"e_1_2_1_8_1","first-page":"62","volume-title":"The Neurosciences, Second Study Program","author":"Angevine J. B.","year":"1970"},{"key":"e_1_2_1_9_1","first-page":"210","article-title":"Autoradiographic study of histogenesis in the cerebral cortex of the mouse","volume":"142","author":"Angevine J. B.","year":"1962","journal-title":"Anat. Rec."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90594-7"},{"key":"e_1_2_1_11_1","first-page":"92","article-title":"Structural and functional development of the mossy fibre system in the hippocampus of the post\u2010natal rat","volume":"239","author":"Bliss T. V. P.","year":"1974","journal-title":"J. Physiol. (London)"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901510203"},{"key":"e_1_2_1_13_1","unstructured":"Caviness V. S. Jr.1977Reeler mutant mouse: A genetic experiment in developing mammalian cortex. In: Soc. for Neuroscience Symposia W. M. Cowan and J. A. Ferrendelli eds. 2:27\u201346."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901450106"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901470206"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108286"},{"key":"e_1_2_1_17_1","first-page":"149","volume-title":"International Review of Physiology","author":"Cowan W. M.","year":"1978"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90344-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb05088.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90170-3"},{"key":"e_1_2_1_21_1","first-page":"135","article-title":"Darstellung rhinencephaler strukturen durch dithizon","volume":"54","author":"Fleischhauar K.","year":"1957","journal-title":"Verh. Anat. Ges. Freiburg"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/cne.901490402","article-title":"Autoradiographic studies of the commissural and ipsilateral association connections of the hippocampus and dentate gyrus of the ret. I. The commissural connections","volume":"149","author":"Gottleib D. I.","year":"1973","journal-title":"J. Comp. Neur."},{"key":"e_1_2_1_23_1","first-page":"1","article-title":"Heavy metals in the brain. A light microscope study of the rat with Timm's sulphide silver method. Methodological considerations and cytological and regional staining patterns","volume":"47","author":"Hang F.\u2010M. \u0160","year":"1973","journal-title":"Adv. Embryol. Cell Biol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900340104"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.887941"},{"key":"e_1_2_1_26_1","first-page":"773","article-title":"Time of origin of neurons in the hippocampal region of the rhesus monkey","volume":"1","author":"Nowakowski R. S.","year":"1975","journal-title":"Neuroscience Abstracts"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901590202"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304660"},{"key":"e_1_2_1_29_1","first-page":"40","volume-title":"Expanding Concepts in Mental Retardation","author":"Sidman R. L.","year":"1968"},{"key":"e_1_2_1_30_1","first-page":"217","volume-title":"Contemporary Research Methods in Neuroanatomy","author":"Sidman R. L.","year":"1970"},{"key":"e_1_2_1_31_1","first-page":"339","article-title":"Reeler, the anatomical substratum. In: Genesis of Neuronal Patterns","volume":"10","author":"Sidman R. L.","year":"1972","journal-title":"NRP Bulletin"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1096-3642.1899.tb00479.x","article-title":"The brain of the edentata","volume":"7","author":"Smith G. E.","year":"1898","journal-title":"Trans. Linn. Soc. (Lond.), 2. Ser., Zool."},{"key":"e_1_2_1_33_1","first-page":"721","article-title":"The morphogenesis of the hippocampus in the normal and reeler mutant mouse","volume":"187","author":"Stanfield B.","year":"1977","journal-title":"Anat. Rec."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850302"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901290105"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901290106"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901300204"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901310402"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901310403"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901320105"},{"key":"e_1_2_1_41_1","first-page":"998","volume-title":"Handbuch der kiroskopischen Anatomie des Menschen. 4 Band, Nervensystem. 9. Teil, Allocortex","author":"Stephen H.","year":"1975"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901730104"},{"key":"e_1_2_1_43_1","unstructured":"Zimmer J. andF.\u2010M. \u0160Haug1975The development of laminar terminal fields in the hippocampus subiculum and fascia dentata of the rat: Observational with the Timm sulphide silver method. 7th International Neurobiology Meeting on Afferent and Intrinsic Organization of Laminated Structures in the Brain G\u00f6ttingen 1975."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901790309"}],"container-title":["Journal of Comparative Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcne.901850303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cne.901850303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:21:25Z","timestamp":1699834885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cne.901850303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1002\/cne.901850303"],"URL":"https:\/\/doi.org\/10.1002\/cne.901850303","archive":["Portico"],"relation":{},"ISSN":["0021-9967","1096-9861"],"issn-type":[{"value":"0021-9967","type":"print"},{"value":"1096-9861","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}