{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:25Z","timestamp":1761017125531},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":17414,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1968,5]]},"abstract":"<jats:p>Amiloride is a new diuretic drug producing moderate natriuretic effects coupled with prominent potassium retention. Though chemically distinct, this compound has some structural similaritites to triamterene, which it also resembles in its effects in normal human subjects, adrenalectomized rats, and on sodium transport across the isolated frog skin. It has no appreciable effect on the urinary concentrating mechanisms. These actions suggest a primary, direct effect upon the distal renal tubule. A dose\u2010response relationship in man is obtained with little increase in effect above 40 mg. At lower doses the effects are manifested within the first 10 hours after administration. Doses above 40 mg. prolong these effects to 24 hours.<\/jats:p>","DOI":"10.1002\/cpt196893318","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:47:49Z","timestamp":1451954869000},"page":"318-327","source":"Crossref","is-referenced-by-count":48,"title":["Pharmacological effects in animals and normal human subjects of the diuretic amiloride hydrochloride (MK\u2010870&gt;"],"prefix":"10.1111","volume":"9","author":[{"given":"Walten I.","family":"Baba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel F.","family":"Lant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Townshend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196893318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196893318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196893318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:34:15Z","timestamp":1699364055000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196893318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1968,5]]}},"alternative-id":["10.1002\/cpt196893318"],"URL":"https:\/\/doi.org\/10.1002\/cpt196893318","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,5]]}}}