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The overall responsiveness had declined by 4 weeks, however, probably due to the nonreplicating character of the early peripherally seeded B cells. Furthermore, these chickens failed to give a memory response. B cells with self\u2010replicating and memory potential are seeded later than 4 days posthatching. However, 7 day Bx still produced a selective suppression of the primary IgG response while the IgM response, although delayed, reached a normal peak titer. Treatment of memory cells <jats:italic>in vitro<\/jats:italic> with anti\u2010\u03bc serum interfered with the adoptive transfer of both IgM and IgG responses. The data are interpreted in terms of sequential seeding of IgM and IgG precursors of the anti\u2010HSA clones, both of which maintain membrane\u2010bound \u03bc\u2010chain antigen.<\/jats:p>","DOI":"10.1002\/eji.1830031210","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T22:43:05Z","timestamp":1172616185000},"page":"789-793","source":"Crossref","is-referenced-by-count":14,"title":["Sequential recruitment of antibody class\u2010committed B lymphocytes during ontogeny"],"prefix":"10.1002","volume":"3","author":[{"given":"J.","family":"Ivanyi","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"493","volume":"6","author":"Ivanyi J.","year":"1970","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_3_2","first-page":"1274","volume":"63","author":"Koshland M. 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