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This was demonstrated by rat liver perfusions with semisynthetic medium containing diluted (1:200) IgA myeloma serum. During perfusion, the cannulated bile displayed increasingly high levels of this IgA, with a bile to medium ratio of 38 after 1 h of perfusion; at the same time, there was a 40% drop of the rat monoclonal IgA concentration in the medium, which was not observed for rat IgG<jats:sub>2a<\/jats:sub> and albumin. All of the monoclonal biliary IgA was bound to secretory component. The rat liver is thus able to actively secrete a monoclonal IgA from the circulation into bile against a strong concentration gradient.<\/jats:p>","DOI":"10.1002\/eji.1830080210","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T09:36:45Z","timestamp":1172655405000},"page":"123-126","source":"Crossref","is-referenced-by-count":156,"title":["Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile"],"prefix":"10.1002","volume":"8","author":[{"given":"G. D. 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