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MCF has an apparent molecular weight of \u223c15000 and is biologically and biochemically indistinguishable from interleukin 1. MCF therefore belongs to the well\u2010documented nonimmune biological activities attributed to interleukin 1. Studies on the mechanisms of production and action of such monokine(s) have been difficult in view of the minute quantities produced by freshly isolated cells or from human monocytic lines. Starting from lectin\u2010stimulated human blood mononuclear cells, we have isolated poly(A) RNA and studied its translation following microinjection into <jats:italic>Xenopus laevis<\/jats:italic> oocytes. The mRNA translation products stimulated collagenase and prostaglandin E<jats:sub>2<\/jats:sub> production in human rheumatoid synovial cells and dermal fibroblasts. The size of MCF\u2010mRNA was estimated to be 10 S. The mRNA of a member of the interleukin 1 family can now be studied in a system based on a specific and direct relevant biological assay and eventually compared with those of other monokines.<\/jats:p>","DOI":"10.1002\/eji.1830141007","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T20:56:12Z","timestamp":1172696172000},"page":"898-901","source":"Crossref","is-referenced-by-count":47,"title":["Induction of human interleukin 1 mRNA measured by collagenase\u2010 and prostaglandin E<sub>2<\/sub>\u2010stimulating activity in rheumatoid synovial cells"],"prefix":"10.1002","volume":"14","author":[{"given":"Jean\u2010Michel","family":"Dayer","sequence":"first","affiliation":[]},{"given":"Carolyn","family":"Zavadil\u2010Grob","sequence":"additional","affiliation":[]},{"given":"Catherine","family":"Ucla","sequence":"additional","affiliation":[]},{"given":"Bernard","family":"Mach","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(82)80027-3"},{"key":"e_1_2_1_3_2","first-page":"257","volume":"41","author":"Oppenheim J. 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