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In contrast to these findings, we find that IgE\u2010secreting tumors do not cause a loss of CD23 expression on host splenic B cells. Decreased expression of CD23 on B cells induced by plasma cell tumors requires direct contact between tumor cells and B cells; and other host cells are not involved. The loss of surface CD23 expression is associated with a decrease in steady\u2010state CD23 mRNA levels in B cells from plasma cell tumor\u2010bearing mice. Interestingly, loss of CD23 mRNA is observed even in B cells from mice with IgE\u2010secreting tumors, where we find surface CD23 protein expression to be similar to that of normal mice. The maintenance of surface CD23 expression on B cells in mice with IgE\u2010secreting tumors is dependent solely on the presence of IgE, and is not a tumorspecific effect. Therefore, we conclude that <jats:italic>in vivo<\/jats:italic>, IgE secreted by plasma cell tumors can result in the maintenance of normal levels of surface CD23 expression by a post\u2010transcriptional mechanism, even when the tumor induces a down\u2010regulation of CD23 mRNA levels.<\/jats:p>","DOI":"10.1002\/eji.1830250817","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T01:17:47Z","timestamp":1172798267000},"page":"2228-2233","source":"Crossref","is-referenced-by-count":4,"title":["Plasma cell tumors decrease CD23 mRNA expression <i>in vivo<\/i> in murine splenic B cells"],"prefix":"10.1002","volume":"25","author":[{"given":"Melanie C.","family":"Ruzek","sequence":"first","affiliation":[]},{"given":"Ambika","family":"Mathur","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.003203"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb24599.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(86)90151-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.4049\/jimmunol.139.9.2865","volume":"139","author":"Mathur A.","year":"1987","journal-title":"J. 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