{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:53:44Z","timestamp":1758477224753},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":14429,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1967,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The specificity of the membrane immunofluorescence reaction obtained upon the exposure of viable Burkitt lymphoma biopsy cells to the sera of certain Burkitt lymphoma patients (Klein et al., 1966 a, b) was studied by testing representative negative and positive sera against Burkitt lymphoma cells and normal bone marrow cells from the same donor, as well as against a panel of allogeneic normal lymph node cells and chronic myeloid leukemia cells from Swedish patients. Sera giving highly positive reactions with Burkitt lymphoma cells failed to react or reacted only exceptionally with normal bone marrow cells of the same donors or the allogeneic non\u2010Burkitt target cells. In contrast, an isoimmune serum from a multiply transfused donor gave highly positive reactions against both Burkitt and non\u2010Burkitt target cells. Taken together with previous results, these findings speak against the involvement of blood group or transplantation antigens, leaving two main explanations: (a) a tumor\u2010specific reaction, similar to the findings on virus\u2010induced mouse lymphomas: (b) preferential non\u2010specific binding to Burkitt lymphoma cell surfaces of some globulin fraction appearing in the serum of Burkitt lymphoma patients after chemotherapeutically induced regression.<\/jats:p>","DOI":"10.1002\/ijc.2910020106","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:39:01Z","timestamp":1171888741000},"page":"27-36","source":"Crossref","is-referenced-by-count":27,"title":["Further studies on the membrane immunofluorescence reaction of Burkitt lymphoma cells"],"prefix":"10.1002","volume":"2","author":[{"given":"Eva","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl\u2010Axel","family":"Hamberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"179","article-title":"Further studies on the treatment of Burkitt's lymphoma","volume":"43","author":"Clifford P.","year":"1966","journal-title":"East African Med. J."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Klein G. Clifford P. Klein E. andStjernsw\u00e4rd J. Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction inJ. H. Burchenal (ed.) Int. Union Against Cancer Symposium on the Chemotherapy of Burkitt's lymphoma Kampala(in press) (1966a).","DOI":"10.1073\/pnas.55.6.1628"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.55.6.1628"},{"key":"e_1_2_1_5_1","first-page":"547","article-title":"Antigenic properties of lymphomas induced by the Moloney agent","volume":"32","author":"Klein G.","year":"1964","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/2061163a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.114.4.415"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.15.020164.001123"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910020106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910020106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T03:29:19Z","timestamp":1699759759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910020106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,1,15]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1967,1,15]]}},"alternative-id":["10.1002\/ijc.2910020106"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910020106","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,1,15]]}}}