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A wide variety of tumors were included in the tests, namely malignant melanomas, carcinomas of the colon, breast, ovary, endometrium, kidney, cervix uteri, lung, larynx, bladder, Fallopian tube, lip, seminomas and sarcomas.<\/jats:p><jats:p>Sera from 67 out of 81 patients with growing neoplasms were found to block the cytotoxic effect of specifically immune lymphocytes. A blocking effect was seen both when the tumor cells, lymphocytes and sera were derived from the same patients and when the lymphocytes and sera were taken from different donors who had the same types of tumor as the target cells. No blocking was seen when the same sera were tested on tumors of histological types other than those of the respective serum donors.<\/jats:p><jats:p>A blocking serum activity was seen in only three of 19 patients who were symptomfree after tumor therapy. The findings thus suggest that there is a correlation between tumor growth <jats:italic>in vivo<\/jats:italic> and the presence of a blocking serum activity <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910070206","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T13:45:34Z","timestamp":1171892734000},"page":"226-237","source":"Crossref","is-referenced-by-count":314,"title":["Blocking of cell\u2010mediated tumor immunity by sera from patients with growing neoplasms"],"prefix":"10.1002","volume":"7","author":[{"given":"Ingegerd","family":"Hellstr\u00f6m","sequence":"first","affiliation":[]},{"given":"Hans Olov","family":"Sj\u00f6gren","sequence":"additional","affiliation":[]},{"given":"Glenn","family":"Warner","sequence":"additional","affiliation":[]},{"given":"Karl Erik","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1410","article-title":"The use of enhancement in studying tumor antigens","volume":"28","author":"Batchelor K. 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