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Chromosome studies show a modal number of 63 with three distinct marker chromosomes and a small ring chromosome. The malignant nature of the PANC\u20101 cell line was verified by: (1) the ready growth of PANC\u20101 cells in soft agar and on top of a fibroblast monolayer; and (2) the formation of a progressively growing anaplastic carcinoma after injection of a nude\u2010athymic mouse with PANC\u20101 cells.<\/jats:p>","DOI":"10.1002\/ijc.2910150505","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T15:55:24Z","timestamp":1171900524000},"page":"741-747","source":"Crossref","is-referenced-by-count":408,"title":["Establishment of a continuous tumor\u2010cell line (PANC\u20101) from a human carcinoma of the exocrine pancreas"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael","family":"Lieber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joann","family":"Mazzetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Nelson\u2010Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Todaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(70)90250-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4005.157"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1973.tb45654.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/51.5.1417"},{"key":"e_1_2_1_6_1","first-page":"1531","article-title":"Development of invasive tumors in the \u201cnude\u201d mouse after injection of cultured human melanoma cells","volume":"48","author":"Giovanella B. 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