{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:05Z","timestamp":1762160585002},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":11110,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1976,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The B95\u20108 strain of Epstein\u2010Barr virus (EBV) induced colony formation of human umbilical cord\u2010blood leukocytes in soft agar medium. One\u2010hit response relationship between the number of colonies and the virus dose was observed with high dilutions of the virus preparation. However, there was a presumed cell\u2010killing effect with low dilutions of virus. The colonies were similarly induced, but with a lower efficiency, in adult peripheral blood leukocyte cultures infected with the virus. The colony\u2010forming activity of EBV was neutralized by anti\u2010EBV\u2010positive but not by negative human sera. The cells in colonies were capable of growing continuously and carried EBV\u2010associated nuclear antigen. Thus, it was evident that the colony formation was caused by clonal transformation by EBV.<\/jats:p>","DOI":"10.1002\/ijc.2910170207","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:04:35Z","timestamp":1171901075000},"page":"191-196","source":"Crossref","is-referenced-by-count":36,"title":["Clonal transformation of human leukocytes by Epstein\u2010barr virus in soft agar"],"prefix":"10.1002","volume":"17","author":[{"given":"Naoki","family":"Yamamoto","sequence":"first","affiliation":[]},{"given":"Yorio","family":"Hinuma","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio233124a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.63.3.740"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3792.1064"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910100119"},{"key":"e_1_2_1_6_1","first-page":"65","article-title":"Biology of a herpes\u2010type virus associated with Burkitt lymphoma cell lines","volume":"7","author":"Hinuma Y.","year":"1969","journal-title":"Gann Monograph"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31677"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196811)22:6<1089::AID-CNCR2820220603>3.0.CO;2-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910150511"},{"key":"e_1_2_1_10_1","first-page":"1129","article-title":"Chromosome and cloning efficiencies of hematopoietic cell lines derived from patients with leukemia, melanoma, myeloma and Burkitt lymphoma","volume":"43","author":"Huang C. C.","year":"1969","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-128-33223"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.6.1365"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.111.293"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910150205"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/54.1.65"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(64)90301-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.1.190"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35810"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.4006"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.3.591"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-17-2-233"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040760111"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910030619"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140115"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910110302"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/jvi.15.5.1065-1072.1975","article-title":"Assay for Epstein\u2010Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood","volume":"15","author":"Robinson J.","year":"1975","journal-title":"J. Virol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jnci\/50.2.307","article-title":"Antigenic expression and colony formation of lymphoblastoid cell lines after superinfection with Epstein\u2010Barr virus","volume":"50","author":"Rocchi G.","year":"1973","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910150108"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140609"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910170207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910170207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:26:31Z","timestamp":1699802791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910170207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2,15]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,2,15]]}},"alternative-id":["10.1002\/ijc.2910170207"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910170207","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,2,15]]}}}